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Neurologic Derangement and Regional Cerebral Oxygen Desaturation Associated with Patency of the Circle of Willis during Carotid Endarterectomy

Title
Neurologic Derangement and Regional Cerebral Oxygen Desaturation Associated with Patency of the Circle of Willis during Carotid Endarterectomy
Authors
ChoiB.-M.ParkS.-K.ShinS.ChoY.-P.KwonT.-W.Y.-J.LeeE.-K.NohG.-J.
Ewha Authors
이은경
SCOPUS Author ID
이은경scopus
Issue Date
2015
Journal Title
Journal of Cardiothoracic and Vascular Anesthesia
ISSN
1053-0770JCR Link
Citation
vol. 29, no. 5, pp. 1200 - 1205
Keywords
carotid endarterectomycircle of Willisregional anesthesiaregional cerebral oxygen saturation
Publisher
W.B. Saunders
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives To explore the relationship between the maximal fractional decrease of regional cerebral oxygen saturation (rSO2) in neurologic derangement and the patency of the circle of Willis and contralateral carotid artery stenosis. Design A prospective observational study. Settings A tertiary-care university hospital Participants This study enrolled 307 patients undergoing carotid endarterectomy under regional anesthesia. Interventions No interventions. Measurements and Main Results Magnetic resonance angiography and carotid color-duplex ultrasound were performed, and the rSO2 was recorded. The relationship between the maximal fractional decrease of rSO2 from preclamp baseline against shunt insertion and patency of the circle of Willis was analyzed by a 2-way analysis of variance. Receiver operating characteristic analysis of the maximal fractional decrease of rSO2 also was performed to calculate the cut-off value for detecting neurologic derangement. In addition, probability of shunt insertion was estimated by logistic regression. Patency of the circle of Willis did not influence the maximal fractional decrease of rSO2. When both anterior and posterior circulations were nonpatent, the degree of contralateral carotid artery stenosis (Contra) was 54.7%±29.0% versus 40.7%±26.0% in patients with versus without shunting, respectively (p<0.05). The cut-off value of rSO2 for predicting shunt insertion was 25.8%, regardless of the patency of the circle of Willis. Probability of shunt insertion for nonpatent anterior circulation = exp(-2.02+0.02×Contra)/[1+exp(-2.02+0.02×Contra)]. Conclusions The rSO2 can be used to predict shunt insertion, regardless of the patency of the circle of Willis. The probability of shunt insertion increased with increasing degree of contralateral carotid artery stenosis in the absence of anterior circulation in the circle of Willis. © 2015 Elsevier Inc.
DOI
10.1053/j.jvca.2015.05.059
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자연과학대학 > 통계학전공 > Journal papers
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