Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김윤근 | - |
dc.contributor.author | 최준표 | - |
dc.date.accessioned | 2016-08-29T12:08:22Z | - |
dc.date.available | 2016-08-29T12:08:22Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | OAK-15393 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230733 | - |
dc.description.abstract | Atherosclerosis is a chronic progressive inflammatory disorder and the leading cause of cardiovascular mortality. Here we assessed the dynamic changes of T-cell-derived cytokines, such as inteferon (IFN)<inf>-γ</inf>, interleukin (IL)-17 and IL-4, during the progression of atherosclerosis in apolipoprotein E-null (ApoE-/-) mice, to understand the role of immune responses in different stages of atherosclerosis. Male ApoE-/- mice were fed a high-fat, western-type diet (WD: 21% lipid, 1.5% cholesterol) after 5 weeks of age and were compared with C57BL/6 wild-type control mice fed a standard chow diet. Atherosclerotic lesions appeared in the aortic sinus of ApoE-/- mice 4 weeks after WD and the lesions progressed and occupied >50% of the total sinus area 16 weeks after WD. Aortic IL-17 mRNA and protein expression started to increase in ApoE-/- mice after 4 weeks on the WD and peaked at around 8-12 weeks on the WD. In terms of systemic expression of T-cell-derived cytokines, IL-17 production from splenocytes after anti-CD3/CD28 stimuli increased from 4 weeks on the WD, peaked at 12 weeks and returned to control levels at 16 weeks. The production of IFN<inf>-γ</inf> and IL-4 (Th1 and Th2 cytokines, respectively) from splenocytes was delayed compared with IL-17. Taken together, the present data indicate that Th17 cell response may be involved at an early stage in the development of atherosclerosis. © 2015 KSBMB. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | The enhanced expression of IL-17-secreting T cells during the early progression of atherosclerosis in ApoE-deficient mice fed on a western-type diet | - |
dc.type | Article | - |
dc.relation.volume | 47 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.journaltitle | Experimental and Molecular Medicine | - |
dc.identifier.doi | 10.1038/emm.2015.19 | - |
dc.identifier.wosid | WOS:000358594500003 | - |
dc.identifier.scopusid | 2-s2.0-84942092009 | - |
dc.author.google | Jeon | - |
dc.author.google | U.S. | - |
dc.author.google | Choi | - |
dc.author.google | J.-P. | - |
dc.author.google | Kim | - |
dc.author.google | Y.-S. | - |
dc.author.google | Ryu | - |
dc.author.google | S.-H. | - |
dc.author.google | Y.-K. | - |
dc.contributor.scopusid | 김윤근(7410211755;7410198224) | - |
dc.contributor.scopusid | 최준표(34867798100) | - |
dc.date.modifydate | 20230120132215 | - |