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Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride
- Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride
- Lee, Ha Na; Lee, Young-Suk; Han, Deok Hyun; Lee, Kyu-Sung
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- LUTS-LOWER URINARY TRACT SYMPTOMS
- 1757-5664; 1757-5672
- vol. 9, no. 2, pp. 67 - 74
- 5-reductase inhibitor; bladder outlet obstruction; bladder wall thickness; lower urinary tract symptom; ultrasound estimated bladder weight
- SCIE; SCOPUS
- ObjectivesTo investigate the change of bladder wall hypertrophy to relieve bladder outlet obstruction (BOO) by treatment with 5-reductase inhibitor. MethodsMen who have BOO confirmed by urodynamic study (BOO index 40) were treated with dutasteride 0.5mg once a day for 6months. We measured ultrasound estimated bladder weight (UEBW), UEBW divided by body surface area (UEBW/BSA), and bladder wall thickness (BWT) before and after treatment. Changes in LUTS parameters were assessed by using the International Prostate Symptom Score, uroflowmetry, residual urine volume, prostate volume, serum prostate-specific antigen (PSA), and LUTS outcome scores (LOS). Correlation between the change of LUTS parameters and UEBW, UEBW/BSA, and BWT were evaluated. We assessed the changes of bladder wall hypertrophy according to the results of benefit, satisfaction, and willingness to continue (BSW) questionnaire. ResultsThirty patients completed the 6-month study. The mean UEBW was 47.107.79g before and 50.07 +/- 5.39g after dutasteride treatment (P=0.259). The mean UEBW/BSA was 26.47 +/- 4.30g/m(2) before and 28.2 +/- 3.53g/m(2) after treatment (P=0.253), and there was no definite change in mean BWT after treatment (P=0.301). Most LUTS parameters including LOS significantly improved. Increased BOO index value was related to decreased BWT (=0.361, P=0.049). There was no definite change in mean UEBW, UEBW/BSA, and BWT according to the results of the BSW questionnaire. ConclusionsThere was no change in UEBW, UEBW/BSA and BWT despite improving most clinical parameters suggesting BOO. The changes of bladder wall hypertrophy parameters still have limitations to directly reflect the relief of BOO.
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