View : 100 Download: 7

What is the most appropriate lipid profile ratio predictor for insulin resistance in each sex? A cross-sectional study in Korean populations (The Fifth Korea National Health and Nutrition Examination Survey)

Title
What is the most appropriate lipid profile ratio predictor for insulin resistance in each sex? A cross-sectional study in Korean populations (The Fifth Korea National Health and Nutrition Examination Survey)
Authors
Byun A.R.Lee S.W.Lee H.S.Shim K.W.
Ewha Authors
이상화이홍수심경원
SCOPUS Author ID
이상화scopus; 이홍수scopus; 심경원scopus
Issue Date
2015
Journal Title
Diabetology and Metabolic Syndrome
ISSN
1758-5996JCR Link
Citation
vol. 7, no. 1
Keywords
Blood cholesterolHOMA-IRInsulin resistanceLDL-cholesterol/HDL-cholesterol ratioNon-HDL-cholesterol/HDL-cholesterol ratio
Publisher
BioMed Central Ltd.
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Insulin resistance (IR) reduces reactivity of the target organ to blood insulin. Researchers have attempted to evaluate IR using various serum lipid concentration ratios. We aimed to determine the most strongly IR-predictive lipid profile ratios for each sex by studying associations between lipid concentration ratios and IR using data from the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1) 2010. Methods: Overall, 8958 individuals participated in health interview and examination surveys. Among them, 1910 individuals who completed physical examinations and 8-h fasting blood tests and were older than 20 years of age were enrolled (929 men and 981 women). The lipid-ratio-related study outcomes were the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C), triglyceride (TG)/HDL-C, and non-HDL-C (LDL-C∈+∈TG/5)/HDL-C ratios. We divided subjects into 4 groups according to lipid profile ratio quartiles for a comparison of homeostasis model assessment (HOMA)-IR values. Regression analyses were performed after adjusting for the confounding factors of age, body mass index, and diabetes mellitus history. Results: HOMA-IR values tended to increase significantly along with LDL-C/HDL-C, TG/HDL-C, and non-HDL-C/HDL-C ratios in both sexes. In men, multiple linear regression analyses showed that after adjusting for confounding factors, a significant positive association remained only with the LDL-C/HDL-C ratio (p∈=∈0.0238, R2∈=∈0.3605, root mean squared error [MSE] =0.3512). In women, multiple linear regression analyses showed that after adjusting for confounding factors, significant positive associations remained with the LDL-C/HDL-C (p∈<∈0.0001, R-square∈=∈0.2329, root MSE∈=∈0.3776), TG/HDL-C (p∈=∈0.0001, R2∈=∈0.2373, root MSE∈=∈0.3766), and non-HDL-C/HDL-C ratios (p∈<∈0.0001, R2∈=∈0.2456, root MSE∈=∈0.3745). Conclusion: The LDL-C/HDL-C ratio in men and LDL-C/HDL-C, TG/HDL-C, and non-HDL-C/HDL-C ratios in women might be clinically significant predictors of IR in healthy Korean adults. However, additional large-scale studies are required to confirm these findings. © 2015 Byun et al.
DOI
10.1186/s13098-015-0051-2
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
001.pdf(394.86 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE