Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2016-08-29T12:08:12Z | - |
dc.date.available | 2016-08-29T12:08:12Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 221767 | * |
dc.identifier.other | OAK-15127 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230633 | - |
dc.description.abstract | Regulatory T (T<inf>reg</inf>) cells act as terminators of T cell immuniy during acute phase of viral infection; however, their role and suppressive mechanism in chronic viral infection are not completely understood. In this study, we compared the phenotype and function of T<inf>reg</inf> cells during acute or chronic infection with lymphocytic choriomeningitis virus. Chronic infection, unlike acute infection, led to a large expansion of T<inf>reg</inf> cells and their upregulation of programmed death-1 (PD-1). T<inf>reg</inf> cells from chronically infected mice (chronic T<inf>reg</inf> cells) displayed greater suppressive capacity for inhibiting both CD8+ and CD4+ T cell proliferation and subsequent cytokine production than those from naive or acutely infected mice. A contact between T<inf>reg</inf> and CD8+ T cells was necessary for the potent suppression of CD8+ T cell immune response. More importantly, the suppression required cell-specific expression and interaction of PD-1 on chronic T<inf>reg</inf> cells and PD-1 ligand on CD8+ T cells. Our study defines PD-1 upregulated on T<inf>reg</inf> cells and its interaction with PD-1 ligand on effector T cells as one cause for the potent T cell suppression and proposes the role of PD-1 on T<inf>reg</inf> cells, in addition to that on exhausted T cells, during chronic viral infection. Copyright © 2015 by The American Association of Immunologists, Inc. | * |
dc.language | English | * |
dc.publisher | American Association of Immunologists | * |
dc.title | PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 194 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5801 | * |
dc.relation.lastpage | 5811 | * |
dc.relation.journaltitle | Journal of Immunology | * |
dc.identifier.doi | 10.4049/jimmunol.1401936 | * |
dc.identifier.wosid | WOS:000355757800027 | * |
dc.identifier.scopusid | 2-s2.0-84931406088 | * |
dc.author.google | Park H.J. | * |
dc.author.google | Park J.S. | * |
dc.author.google | Jeong Y.H. | * |
dc.author.google | Son J. | * |
dc.author.google | Ban Y.H. | * |
dc.author.google | Lee B.-H. | * |
dc.author.google | Chen L. | * |
dc.author.google | Chang J. | * |
dc.author.google | Chung D.H. | * |
dc.author.google | Choi I. | * |
dc.author.google | Ha S.-J. | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |