View : 13 Download: 0

PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells

Title
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells
Authors
Park H.J.Park J.S.Jeong Y.H.Son J.Ban Y.H.Lee B.-H.Chen L.Chang J.Chung D.H.Choi I.Ha S.-J.
Ewha Authors
장준
SCOPUS Author ID
장준scopus
Issue Date
2015
Journal Title
Journal of Immunology
ISSN
221767JCR Link
Citation
vol. 194, no. 12, pp. 5801 - 5811
Publisher
American Association of Immunologists
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Regulatory T (T<inf>reg</inf>) cells act as terminators of T cell immuniy during acute phase of viral infection; however, their role and suppressive mechanism in chronic viral infection are not completely understood. In this study, we compared the phenotype and function of T<inf>reg</inf> cells during acute or chronic infection with lymphocytic choriomeningitis virus. Chronic infection, unlike acute infection, led to a large expansion of T<inf>reg</inf> cells and their upregulation of programmed death-1 (PD-1). T<inf>reg</inf> cells from chronically infected mice (chronic T<inf>reg</inf> cells) displayed greater suppressive capacity for inhibiting both CD8+ and CD4+ T cell proliferation and subsequent cytokine production than those from naive or acutely infected mice. A contact between T<inf>reg</inf> and CD8+ T cells was necessary for the potent suppression of CD8+ T cell immune response. More importantly, the suppression required cell-specific expression and interaction of PD-1 on chronic T<inf>reg</inf> cells and PD-1 ligand on CD8+ T cells. Our study defines PD-1 upregulated on T<inf>reg</inf> cells and its interaction with PD-1 ligand on effector T cells as one cause for the potent T cell suppression and proposes the role of PD-1 on T<inf>reg</inf> cells, in addition to that on exhausted T cells, during chronic viral infection. Copyright © 2015 by The American Association of Immunologists, Inc.
DOI
10.4049/jimmunol.1401936
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE