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Low Plasma Proportion of Omega 3-Polyunsaturated Fatty Acids Predicts Poor Outcome in Acute Non-Cardiogenic Ischemic Stroke Patients

Title
Low Plasma Proportion of Omega 3-Polyunsaturated Fatty Acids Predicts Poor Outcome in Acute Non-Cardiogenic Ischemic Stroke Patients
Authors
Song, Tae-JinCho, Hyun-JiChang, YoonkyungChoi, KyungsunJung, A-ReumYoun, MinjungShin, Min-JeongKim, Yong-Jae
Ewha Authors
김용재송태진
SCOPUS Author ID
김용재scopus; 송태진scopus; 송태진scopus
Issue Date
2015
Journal Title
JOURNAL OF STROKE
ISSN
2287-6391JCR Link

2287-6405JCR Link
Citation
JOURNAL OF STROKE vol. 17, no. 2, pp. 168 - 176
Keywords
Fatty acids compositionDocosahexaenoic acidEicosapentaenoic acidomega 3-polyunsaturated fatty acidsStroke outcome
Publisher
KOREAN STROKE SOC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background and Purpose Alterations in blood fatty acid (FA) composition are associated with cardiovascular diseases. We investigated whether plasma FA composition was related to stroke severity and functional outcome in acute ischemic stroke patients. Methods We prospectively enrolled 156 patients with first-episode cerebral infarction, within 7 days of symptom onset. The proportion of FAs was analyzed using gas chromatography, and the summation of the omega-3 polyunsaturated fatty acids (omega 3-PUFA), 18:3 omega 3 alpha-linolenic acid, 20:3 omega 3 eicosatrienoic acid, 20:5 omega 3 eicosapentaenoic acid (EPA), and 22:6 omega 3 docosahexaenoic acid (DHA) was reported as Sigma omega 3-PUFAs. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score on admission. Poor functional outcome was defined by modified Rankin scale (mRS) >= 3 at three months after the index stroke. Results Lower proportions of EPA (beta=-0.751), DHA (beta=-0.610), and Sigma omega 3-PUFAs (beta=-0.462) were independently associated with higher NIHSS score, after adjusting for stroke subtype, hemoglobin, high density lipoprotein, high sensitivity C-reactive protein, fasting glucose, 16:0 palmitic acid, and Sigma saturated fatty acids. Moreover, a lower proportion of DHA (odds ratio [OR]: 0.20, 95% confidence interval [CI]: 0.04-0.88), and Sigma omega 3-PUFAs (OR: 0.22, 95% Cl: 0.05-0.84) showed an independent relationship with poor functional outcome after adjusting for age, sex, smoking status, NIHSS score, stroke subtype, and 16:0 palmitic acid. Conclusions Our results demonstrate that omega 3-PUFAs correlated with stroke severity on admission and functional outcomes at 3 months. omega 3-PUFAs are potential blood biomarkers for prognosis of acute non-cardiogenic ischemic stroke patients.
DOI
10.5853/jos.2015.17.2.168
Appears in Collections:
의과대학 > 의학과 > Journal papers
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