Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 김관창 | * |
dc.contributor.author | 권정현 | * |
dc.date.accessioned | 2016-08-29T12:08:10Z | - |
dc.date.available | 2016-08-29T12:08:10Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.other | OAK-15061 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230612 | - |
dc.description.abstract | Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical cord blood-mesenchymal stem cells (hUCB-MSCs) placed in the correct place in the lung and research on changes of hemodynamics, pulmonary pathology, immunomodulation and several gene expressions in monocrotaline (MCT)- induced PAH rat models after hUCB-MSCs transfusion. The rats were grouped as follows: the control (C) group; the M group (MCT 60 mg/kg); the U group (hUCB-MSCs transfusion). They received transfusions via the external jugular vein a week after MCT injection. The mean right ventricular pressure (RVP) was significantly reduced in the U group after the 2 week. The indicators of RV hypertrophy were significantly reduced in the U group at week 4. Reduced medial wall thickness in the pulmonary arteriole was noted in the U group at week 4. Reduced number of intra-acinar muscular pulmonary arteries was observed in the U group after 2 week. Protein expressions such as endothelin (ET)-1, endothelin receptor A (ERA), endothelial nitric oxide synthase (eNOS) and matrix metalloproteinase (MMP)-2 significantly decreased at week 4. The decreased levels of ERA, eNOS and MMP-2 immunoreactivity were noted by immnohistochemical staining. After hUCB-MSCs were administered, there were the improvement of RVH and mean RVP. Reductions in several protein expressions and immunomodulation were also detected. It is suggested that hUCB-MSCs may be a promising therapeutic option for PAH. © 2015 The Korean Academy of Medical Sciences. | * |
dc.language | English | * |
dc.publisher | Korean Academy of Medical Science | * |
dc.subject | Cord blood stem cell transfusion | * |
dc.subject | Gene Expression | * |
dc.subject | Hypertension | * |
dc.subject | Monocrotaline | * |
dc.subject | Pulmonary | * |
dc.title | The effect of umbilical cord blood derived mesenchymal stem cells in monocrotaline-induced pulmonary artery hypertension rats | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 576 | * |
dc.relation.lastpage | 585 | * |
dc.relation.journaltitle | Journal of Korean Medical Science | * |
dc.identifier.doi | 10.3346/jkms.2015.30.5.576 | * |
dc.identifier.wosid | WOS:000354981600010 | * |
dc.identifier.scopusid | 2-s2.0-84952017017 | * |
dc.author.google | Lee H. | * |
dc.author.google | Lee J.C. | * |
dc.author.google | Kwon J.H. | * |
dc.author.google | Kim K.C. | * |
dc.author.google | Cho M.-S. | * |
dc.author.google | Yang Y.S. | * |
dc.author.google | Oh W. | * |
dc.author.google | Choi S.J. | * |
dc.author.google | Seo E.-S. | * |
dc.author.google | Lee S.-J. | * |
dc.author.google | Wang T.J. | * |
dc.author.google | Hong Y.M. | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 김관창(36652690000) | * |
dc.contributor.scopusid | 권정현(57191477869) | * |
dc.date.modifydate | 20240415130647 | * |