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Uric acid and the kidney

Title
Uric acid and the kidney
Authors
Kang D.-H.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2014
Journal Title
Core Concepts in Parenchymal Kidney Disease
Publisher
Springer New York
Indexed
SCOPUS scopus
Abstract
Since the primary site of excretion of uric acid is the kidney, plasma concentration of uric acid is mainly determined by renal handling of uric acid. Although hyperuricemia is common in various spectrum of kidney diseases, it historically has been viewed as an issue of limited interest. Recently uric acid has been resurrected as a potential contributory risk factor in the development and progression of renal disease via its direct effect on renal vasculature and tubules as well as indirect effect mediating hypertension and metabolic syndrome. Most studies documented that an elevated serum uric acid level independently predicts the development of chronic kidney disease (CKD), and several interventional studies demonstrated the beneficial effect of lowering plasma uric acid concentrations on preservation of renal function. Uric acid can also induce acute uric acid nephropathy and renal stone via different mechanisms from the progression of renal disease in CKD. In this chapter, the various spectrum of renal disease in hyperuricemic subject will be discussed with a comprehensive review of uric acid-lowering therapy including the use of xanthine oxidase inhibitor and uricosuric agents. © 2014 Springer Science+Business Media New York. All rights are reserved.
DOI
10.1007/978-1-4614-8166-9_26
ISBN
9781461481669; 1461481651; 9781461481652
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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