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Restoring multidrug resistance-associated protein 3 attenuates cell proliferation in the polycystic kidney

Title
Restoring multidrug resistance-associated protein 3 attenuates cell proliferation in the polycystic kidney
Authors
Chang E.S.Park E.Y.Woo Y.M.Kang D.-H.Hwang Y.-H.Ahn C.Park J.H.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2015
Journal Title
American Journal of Physiology - Renal Physiology
ISSN
3636127JCR Link
Citation
vol. 308, no. 9, pp. F1004 - F1011
Keywords
Cell proliferationCystogenesisMultidrug resistance-associated protein 3 (MRP3)Polycystic kidney
Publisher
American Physiological Society
Indexed
SCOPUS WOS scopus
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by abnormal proliferation of renal tubular epithelial cells, resulting in the loss of renal function. Despite identification of the genes responsible for ADPKD, few effective drugs are currently available for the disease. Thus finding additional effective drug targets is necessary. The functions of multidrug- resistance-associated protein 3 (MRP3) have been reported only in the field of drug resistance, and the renal functions of MRP3 are mostly unknown. In this study, we found that MRP3 was significantly downregulated in kidneys of human patients with ADPKD and polycystic kidney disease (PKD) mouse models. Our results suggest that downregulated MRP3 stimulated renal epithelial cell proliferation through the B-Raf/MEK/ERK signaling pathway. In contrast, we found that restoring MRP3 reduced cell proliferation and cystogenesis in vitro. These results suggest that the renal function of MRP3 is related to renal cell proliferation and cyst formation and that restoring MRP3 may be an effective therapeutic approach for PKD. © 2015 the American Physiological Society
DOI
10.1152/ajprenal.00159.2014
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의학전문대학원 > 의학과 > Journal papers
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