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Cytokine expression of microscopic colitis including interleukin-17

Title
Cytokine expression of microscopic colitis including interleukin-17
Authors
Park E.Park Y.S.Park D.R.Jung S.A.Han D.S.Jang B.I.Kim Y.H.Kim W.H.Jo Y.J.Lee K.H.Lee W.M.Kim E.K.Koo H.S.
Ewha Authors
구혜수정성애
SCOPUS Author ID
구혜수scopus; 정성애scopus
Issue Date
2015
Journal Title
Gut and Liver
ISSN
1976-2283JCR Link
Citation
vol. 9, no. 3, pp. 381 - 387
Keywords
Colitis, collagenousColitis, lymphocyticColitis, microscopicImmunohistochemistry
Publisher
Joe Bok Chung
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background/Aims: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the pathogenic mechanism of microscopic colitis. Methods: This study consisted of six patients with lymphocytic colitis, six patients with collagenous colitis, and six patients with functional diarrhea but normal pathology. We performed an immunohistochemical analysis of the colonic mucosal biopsies to assess the expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-κB, interferon-γ, inducible nitric oxide synthase, and tumor necrosis factor-α. We compared the quantity score of immunohistochemical staining among the groups. Results: The microscopic colitis group showed significantly higher expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-κB, and interferon-γ compared with the control group. Cytokine expression was similar between collagenous colitis and lymphocytic colitis. However, the expression of cyclo-oxygenase-2 was higher in collagenous colitis. Conclusions: Proinflammatory cytokines, including interleukin-17 and interferon-γ, are highly expressed in microscopic colitis. The expression of cyclo-oxygenase-2 was higher in collagenous colitis than in lymphocytic colitis. This study is the first on interleukin-17 expression in microscopic colitis patients. © 2015, Joe Bok Chung. All rights reserved.
DOI
10.5009/gnl13439
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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