Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2016-08-29T12:08:58Z | - |
dc.date.available | 2016-08-29T12:08:58Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0899-9007 | * |
dc.identifier.other | OAK-14762 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230505 | - |
dc.description.abstract | Objective: The apolipoprotein B (. APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. The aim of this study was to investigate the effect of the APOB rs1469513 polymorphism on plasma lipid profiles and obesity-related phenotypes, together with their modulation by dietary intake in Korean individuals. Methods: We analyzed the plasma lipid profiles, obesity-related phenotypes, and dietary intake of 6470 Korean aged 40 to 59 y from the KoGES (Korean Genome Epidemiology Study) database. The effects of APOB rs1469513 on traits, the interaction of APOB rs1469513 and dietary intake on traits were analyzed. Results: Plasma levels of total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (P=0.010), body weight (P = 0.048), and body mass index (P = 0.029) were significantly different in carriers of the A allele and minor G allele of APOB rs1469513. Among individuals whose fat intake was above the median, the difference for the body mass index across genotypes is 1.14% (AA 24.66 kg/m2 versus AG+GG 24.94 kg/m2, P = 0.004) and carriers of the minor G allele had increased odds of being obese (Odds ratios, 1.31; 95% confidence interval, 1.09-1.57; P = 0.004) compared with homozygotes for the A allele. Conclusions: Our findings support a significant association between the APOB rs1469513 variant, plasma lipid profiles, and obesity-related phenotypes. This association has the potential to be modified by dietary fat intake. These results may offer proof that the differences between normal weight and overweight/obese individuals might partly result from different SNPs. © 2015 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Elsevier Inc. | * |
dc.subject | APOB | * |
dc.subject | Gene-diet interaction | * |
dc.subject | Lipid profile | * |
dc.subject | Obesity | * |
dc.subject | Rs1469513 | * |
dc.title | Association between the APOB rs1469513 polymorphism and obesity is modified by dietary fat intake in Koreans | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 653 | * |
dc.relation.lastpage | 658 | * |
dc.relation.journaltitle | Nutrition | * |
dc.identifier.doi | 10.1016/j.nut.2014.10.007 | * |
dc.identifier.wosid | WOS:000352521900005 | * |
dc.identifier.scopusid | 2-s2.0-84933520239 | * |
dc.author.google | Doo M. | * |
dc.author.google | Won S. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |