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Association between the APOB rs1469513 polymorphism and obesity is modified by dietary fat intake in Koreans

Title
Association between the APOB rs1469513 polymorphism and obesity is modified by dietary fat intake in Koreans
Authors
Doo M.Won S.Kim Y.
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2015
Journal Title
Nutrition
ISSN
0899-9007JCR Link
Citation
vol. 31, no. 5, pp. 653 - 658
Keywords
APOBGene-diet interactionLipid profileObesityRs1469513
Publisher
Elsevier Inc.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: The apolipoprotein B (. APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. The aim of this study was to investigate the effect of the APOB rs1469513 polymorphism on plasma lipid profiles and obesity-related phenotypes, together with their modulation by dietary intake in Korean individuals. Methods: We analyzed the plasma lipid profiles, obesity-related phenotypes, and dietary intake of 6470 Korean aged 40 to 59 y from the KoGES (Korean Genome Epidemiology Study) database. The effects of APOB rs1469513 on traits, the interaction of APOB rs1469513 and dietary intake on traits were analyzed. Results: Plasma levels of total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (P=0.010), body weight (P = 0.048), and body mass index (P = 0.029) were significantly different in carriers of the A allele and minor G allele of APOB rs1469513. Among individuals whose fat intake was above the median, the difference for the body mass index across genotypes is 1.14% (AA 24.66 kg/m2 versus AG+GG 24.94 kg/m2, P = 0.004) and carriers of the minor G allele had increased odds of being obese (Odds ratios, 1.31; 95% confidence interval, 1.09-1.57; P = 0.004) compared with homozygotes for the A allele. Conclusions: Our findings support a significant association between the APOB rs1469513 variant, plasma lipid profiles, and obesity-related phenotypes. This association has the potential to be modified by dietary fat intake. These results may offer proof that the differences between normal weight and overweight/obese individuals might partly result from different SNPs. © 2015 Elsevier Inc.
DOI
10.1016/j.nut.2014.10.007
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신산업융합대학 > 식품영양학과 > Journal papers
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