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Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brain

Title
Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brain
Authors
Kim H.S.Kim Y.J.Lee Y.H.Lee Y.-S.Choi H.D.Pack J.-K.Kim N.Ahn Y.H.
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2015
Journal Title
International Journal of Radiation Biology
ISSN
0955-3002JCR Link
Citation
vol. 91, no. 4, pp. 354 - 359
Keywords
Bromodeoxyuridine (BrdU)Cell proliferationDentate gyrusNeurogenesisRadio wavesRatsSubventricular zone
Publisher
Informa Healthcare
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Introduction: Whether exposure to the 848.5 MHz code division multiple access (CDMA) signal affects adult neurogenesis is unclear. Materials and methods: An animal experiment was performed with a reverberation chamber designed as a whole-body CDMA exposure system. Male Sprague-Dawley rats were assigned to three groups (n = 6 per group): Cage-control, sham-exposed, and CDMA-exposed groups. Rats in the CDMA-exposed group were exposed to the CDMA signal at a 2 W/kg whole-body specific absorption rate (SAR) for 1 or 8 h daily, 5 days per week, for 2 weeks. Rats received a single intraperitoneal injection of Bromodeoxyuridine (BrdU) to label proliferative cells daily for the last five consecutive days of CDMA signal exposure. An unbiased stereological method was used to estimate the number of BrdU+ cells in the subventricular zone (SVZ) and dentate gyrus (DG). Results: We found no significant changes in the number of BrdU+ cells in the SVZ or DG in the CDMA-exposed rats, compared with rats in the cage-control and sham-exposed groups (p > 0.05). Conclusion: Our results suggest that exposure to the CDMA signal does not affect neurogenesis in the adult rat brain, at least under our experimental conditions. © 2015 Informa UK, Ltd.
DOI
10.3109/09553002.2014.995382
Appears in Collections:
약학대학 > 약학과 > Journal papers
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