View : 619 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author김건하-
dc.date.accessioned2016-08-29T12:08:54Z-
dc.date.available2016-08-29T12:08:54Z-
dc.date.issued2015-
dc.identifier.issn1041-6102-
dc.identifier.otherOAK-14660-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/230471-
dc.description.abstractBackground: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis. Copyright © 2014 International Psychogeriatric Association.-
dc.languageEnglish-
dc.publisherCambridge University Press-
dc.subjectAlzheimer's disease-
dc.subjectcognitive reserve theory-
dc.subjectcortical thickness-
dc.subjecteducation-
dc.titleHigher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume27-
dc.relation.indexSCIE-
dc.relation.indexSSCI-
dc.relation.indexSCOPUS-
dc.relation.startpage111-
dc.relation.lastpage120-
dc.relation.journaltitleInternational Psychogeriatrics-
dc.identifier.doi10.1017/S1041610214001483-
dc.identifier.wosidWOS:000351055400012-
dc.identifier.scopusid2-s2.0-84927641765-
dc.author.googleCho H.-
dc.author.googleJeon S.-
dc.author.googleKim C.-
dc.author.googleYe B.S.-
dc.author.googleKim G.H.-
dc.author.googleNoh Y.-
dc.author.googleKim H.J.-
dc.author.googleYoon C.W.-
dc.author.googleKim Y.J.-
dc.author.googleKim J.-H.-
dc.author.googlePark S.E.-
dc.author.googleKim S.T.-
dc.author.googleLee J.-M.-
dc.author.googleKang S.J.-
dc.author.googleSuh M.K.-
dc.author.googleChin J.-
dc.author.googleNa D.L.-
dc.author.googleKang D.R.-
dc.author.googleSeo S.W.-
dc.contributor.scopusid김건하(36554502600)-
dc.date.modifydate20230125114714-
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE