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Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: A Korean national survey

Title
Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: A Korean national survey
Authors
Lee S.H.Kim D.S.Kim Y.W.Chung M.P.Uh S.T.Park C.S.Jeong S.H.Park Y.B.Lee H.L.Song J.S.Shin J.W.Yoo N.S.Lee E.J.Lee J.H.Jegal Y.Lee H.K.Park M.S.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2015
Journal Title
Chest
ISSN
0012-3692JCR Link
Citation
vol. 147, no. 2, pp. 465 - 474
Publisher
American College of Chest Physicians
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BACKGROUND: Previous studies have investigated the relationship between occupational and environmental agents and idiopathic pulmonary fibrosis (IPF). However, there have been few studies regarding the prognosis of patients with IPF according to patient occupation. METHODS: We investigated whether occupational dust exposure was associated with clinically decreased lung function and poor prognosis. The Korean Interstitial Lung Disease Research Group conducted a national survey to evaluate the clinical, physiologic, radiologic, and survival characteristics of patients with IPF. A total of 1,311 patients with IPF were stratified into five groups according to their occupation: (1) unemployed or homemakers (n = 628); (2) farmers, fishers, or ranchers (n 5 230); (3) sales or service personnel (n = 131); (4) clerical or professional personnel (n = 151); and (5) specific dust-exposed workers (n = 171). RESULTS: The mean age of subjects at diagnosis, was 67.5 ± 9.7 years. Current smokers were 336 patients, 435 were exsmokers, and 456 were never smokers. Dust-exposed workers showed early onset of IPF (61.3 ± 8.6 years; P < .001) and a longer duration of symptoms at diagnosis (17.0 ± 28.2 months; P = .004). Aging (P = .001; hazard ratio [HR], 1.034; 95% CI, 1.014-1.054), FVC % predicted at diagnosis (P = .004; HR, 0.984; 95% CI, 0.974-0.995), and dust-exposure occupation (P = .033; HR, 1.813; 95% CI, 1.049-3.133) were associated with mortality. CONCLUSIONS: These findings indicate that occupational dust may be an aggravating factor associated with a poor prognosis in IPF. © 2015 American College of Chest Physicians.
DOI
10.1378/chest.14-0994
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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