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Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis

Title
Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis
Authors
Baek J.H.Seo H.K.Jee H.M.Shin Y.H.Han M.Y.Oh E.S.Lee H.J.Kim K.H.
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2013
Journal Title
Korean Journal of Pediatrics
ISSN
1783-1061JCR Link
Citation
vol. 56, no. 7, pp. 289 - 293
Indexed
SCOPUS scopus
Abstract
Purpose: Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. Methods: We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3-11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months or >3 times per year. The complete blood count with differential and total serum concentrations of Immunoglobulin (Ig) E, IgA, IgD, IgM, IgG, and IgG subclasses (IgG1, IgG2, IgG3, and IgG4) of all children were measured. All subjects received 23-polysaccharide pneumococcal vaccination (PPV), and the levels of antibodies to 5 serologic types (4, 6B, 14, 18C, and 23F) of pneumococcal capsular polysaccharide antigens were measured before and after vaccination. Post-PPV antibody titers ≥0.35 μg/mL or with a ≥4-fold increase were considered as positive responses. Results: The titers of IgG, IgA, IgD, and IgM were within normal range in all 16 children, whereas the total IgE concentration was higher than normal in 2 children. IgG1 deficiency was observed in 1 patient and IgG3 deficiency in 3. After PPV, 1 patient failed to respond to all 5 serologic types, 2 failed to respond to 4 serologic types, and 2 failed to respond to 3 serologic types. Conclusion: Clinicians should consider the evaluation of humoral immune functions in children with chronic or recurrent rhinosinusitis who do not respond to prolonged antibiotic treatment. © 2013 by The Korean Pediatric Society.
DOI
10.3345/kjp.2013.56.7.289
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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