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Oxidative stress and the antioxidant enzyme system in the developing brain

Title
Oxidative stress and the antioxidant enzyme system in the developing brain
Authors
Shim S.-Y.Kim H.-S.
Ewha Authors
심소연
SCOPUS Author ID
심소연scopusscopus
Issue Date
2013
Journal Title
Korean Journal of Pediatrics
ISSN
1783-1061JCR Link
Citation
vol. 56, no. 3, pp. 107 - 111
Indexed
SCOPUS scopus
Abstract
Preterm infants are vulnerable to the oxidative stress due to the production of large amounts of free radicals, antioxidant system insufficiency, and immature oligodendroglial cells. Reactive oxygen species (ROS) play a pivotal role in the development of periventricular leukomalacia. The three most common ROS are superoxide (O2•-), hydroxyl radical (OH•), and hydrogen peroxide (H2O2). Under normal physiological conditions, a balance is maintained between the production of ROS and the capacity of the antioxidant enzyme system. However, if this balance breaks down, ROS can exert toxic effects. Superoxide dismutase, glutathione peroxidase, and catalase are considered the classical antioxidant enzymes. A recently discovered antioxidant enzyme family, peroxiredoxin (Prdx), is also an important scavenger of free radicals. Prdx1 expression is induced at birth, whereas Prdx2 is constitutively ex- pressed, and Prdx6 expression is consistent with the classical antioxidant enzymes. Several antioxidant substances have been studied as potential therapeutic agents; however, further preclinical and clinical studies are required before allowing clinical application. © 2013 by The Korean Pediatric Society.
DOI
10.3345/kjp.2013.56.3.107
Appears in Collections:
의료원 > 의료원 > Journal papers
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