Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.contributor.author | 김혜순 | * |
dc.contributor.author | 손세정 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 김관창 | * |
dc.date.accessioned | 2016-08-28T11:08:06Z | - |
dc.date.available | 2016-08-28T11:08:06Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1783-1061 | * |
dc.identifier.other | OAK-13955 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229894 | - |
dc.description.abstract | Purpose: Tumor necrosis factor (TNF)-α is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-α antagonist) treatment on pathologic findings and gene expression in a monocrotaline-induced pulmonary hypertension rat model. Methods: Six-week-old male Sprague-Dawley rats were allocated to 3 groups: control (C), single subcutaneous injection of normal saline (0.1 mL/kg); monocrotaline (M), single subcutaneous injection of monocrotaline (60 mg/kg); and monocrotaline + infliximab (M+I), single subcutaneous injection of monocrotaline plus single subcutaneous injection of infliximab (5 mg/kg). The rats were sacrificed after 1, 5, 7, 14, or 28 days. We examined changes in pathology and gene expression levels of TNF-α, endothelin-1 (E T-1), endothelin receptor A (ERA), endothelial nitric oxide synthase (eNOS), matrix metalloproteinase (MMP) 2, and tissue inhibitor of matrix metalloproteinase (TIMP). Results: The increase in medial wall thickness of the pulmonary arteriole in the M+I group was significantly lower than that in the M group on day 7 after infliximab treatment (P<0.05). The number of intraacinar muscular arteries in the M+I group was lower than that in the M group on days 14 and 28 (P< 0.05). Expression levels of TNF-α, ET-1, ERA, and MMP2 were significantly lower in the M+I group than in the M group on day 5, whereas eNOS and TIMP expressions were late in the M group (day 28). Conclusion: Infliximab administration induced early changes in pathological findings and expression levels of TNF-α, and MMP2 in a monocrotaline-induced pulmonary hypertension rat model. © 2013 by The Korean Pediatric Society. | * |
dc.language | English | * |
dc.title | An inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotalineinduced pulmonary hypertensive rats model | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 56 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 116 | * |
dc.relation.lastpage | 124 | * |
dc.relation.journaltitle | Korean Journal of Pediatrics | * |
dc.identifier.doi | 10.3345/kjp.2013.56.3.116 | * |
dc.identifier.scopusid | 2-s2.0-84875181979 | * |
dc.author.google | Kwon J.H. | * |
dc.author.google | Kim K.C. | * |
dc.author.google | Cho M.-S. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Sohn S. | * |
dc.author.google | Hong Y.M. | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.contributor.scopusid | 김혜순(55663596500) | * |
dc.contributor.scopusid | 손세정(56577409300) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 김관창(36652690000) | * |
dc.date.modifydate | 20240415130647 | * |