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Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism

Title
Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism
Authors
Han K.-H.
Ewha Authors
한기환
SCOPUS Author ID
한기환scopus
Issue Date
2011
Journal Title
Electrolyte and Blood Pressure
ISSN
1738-5997JCR Link
Citation
vol. 9, no. 2, pp. 45 - 49
Indexed
SCOPUS; KCI scopus
Abstract
Renal ammonia metabolism is the predominant component of net acid excretion and new bicarbonate generation. Renal ammonia metabolism is regulated by acid-base balance. Both acute and chronic acid loads enhance ammonia production in the proximal tubule and secretion into the urine. In contrast, alkalosis reduces ammoniagenesis. Hypokalemia is a common electrolyte disorder that significantly increases renal ammonia production and excretion, despite causing metabolic alkalosis. Although the net effects of hypokalemia are similar to metabolic acidosis, molecular mechanisms of renal ammonia production and transport have not been well understood. This mini review summarizes recent findings regarding renal ammonia metabolism in response to chronic hypokalemia. Copyright © 2011 The Korean Society of Electrolyte Metabolism.
DOI
10.5049/EBP.2011.9.2.45
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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