Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승정 | * |
dc.date.accessioned | 2016-08-28T11:08:52Z | - |
dc.date.available | 2016-08-28T11:08:52Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1226-3303 | * |
dc.identifier.other | OAK-13832 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229777 | - |
dc.description.abstract | Background/Aims: Chronic inflammatory status is a possible risk factor for vascular access dysfunction in hemodialysis (HD) patients, but susceptibility differences appear among individuals. Interleukin (IL)-6 is a well-known inflammatory cytokine with various polymorphisms. We examined whether IL-6 polymorphisms are associated with vascular access dysfunction in HD patients. Methods: A total of 80 HD patients (including 42 diabetic patients) were enrolled. Polymorphisms in the IL-6 gene promoter (-634 C/G and -174 G/C) were studied using restriction length polymorphism polymerase chain reaction analysis. Vascular access patency was compared between the patient groups with respect to IL-6 polymorphisms. An additional 89 healthy individuals were enrolled in the control group. Plasma IL-6 levels were de termined by enzymelinked immunosorbent assay. Results: The GG genotype and G allele at position -634 in the IL-6 promoter were more frequently observed in HD patients than in controls. Furthermore, the distribution of the -634 polymorphism differed according to vascular access patency in non-diabetic HD patients. However, the G allele was not a significant risk factor for early access failure. No significant association appeared between the IL-6 -634 C/G polymorphism and plasma IL-6 levels. The C allele of the IL-6 -174 G/C polymorphism was not detected in our study population. Conclusions: The IL-6 -634 G allele appears with greater frequently in patients with end-stage renal disease and may be associated with vascular access dysfunction in non-diabetic HD patients. © 2012 The Korean Association of Internal Medicine. | * |
dc.language | English | * |
dc.title | Interleukin-6 -634 C/G and -174 G/C polymorphisms in Korean patients undergoing hemodialysis | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 327 | * |
dc.relation.lastpage | 337 | * |
dc.relation.journaltitle | Korean Journal of Internal Medicine | * |
dc.identifier.doi | 10.3904/kjim.2012.27.3.327 | * |
dc.identifier.scopusid | 2-s2.0-84867043973 | * |
dc.author.google | Ryu J.-H. | * |
dc.author.google | Kim S.-J. | * |
dc.contributor.scopusid | 김승정(8619054500) | * |
dc.date.modifydate | 20240419142141 | * |