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Postoperative B-type natriuretic peptide levels associated with prolonged hospitalization in hypertensive patients after non-cardiac surgery

Title
Postoperative B-type natriuretic peptide levels associated with prolonged hospitalization in hypertensive patients after non-cardiac surgery
Authors
Park J.H.Shin G.J.Ryu J.I.Pyun W.B.
Ewha Authors
신길자편욱범
SCOPUS Author ID
신길자scopus; 편욱범scopus
Issue Date
2012
Journal Title
Korean Circulation Journal
ISSN
1738-5520JCR Link
Citation
vol. 42, no. 8, pp. 521 - 527
Indexed
SCIE; SCOPUS; KCI scopus
Abstract
Background and Objectives: B-type natriuretic peptide (BNP) is an important marker for the diagnosis of heart failure and is useful towards predicting morbidity and mortality after non-cardiac surgery. Nevertheless, information on the relationship between postoperative BNP levels and perioperative prognosis after non-cardiac surgery is scarce. The purpose of the study was to assess whether postoperative BNP levels could be used as a predictor of prolonged hospitalization in elderly hypertensive patients after non-cardiac surgery. Subjects and Methods: Ninety-seven (97) patients, aged 55 years or older (mean age: 73.12±10.05 years, M : F=24 : 73) were enrolled in a prospective study from May 2005 through August 2010. All patients underwent total knee or hip replacement Postoperative BNP and other diagnostic data were recorded within 24 hours of surgery. Patients that required a prolonged hospital stay due to operative causes, such as wound infection and re-operation, were excluded. Results: The length of hospital stay was significantly correlated with postoperative BNP levels (p=0.031). Receiver operating characteristic curves demonstrated postoperative BNP levels as predictors of hospital stay ≥30 days with areas under the curve of 0.774 (95% confidence interval: 0.679-0.87, p<0.0001). A BNP cut-off value above 217.5 pg/mL had a sensitivity of 80.6% and a specificity of 66.7% for predicting postoperative hospital stays of 30 days or more. Conclusion: Postoperative BNP levels may predict the length of hospital stays after non-cardiac surgery in hypertensive patients. Elevated BNP levels were associated with prolonged hospitalization after elective orthopedic surgery. Copyright © 2012 The Korean Society of Cardiology.
DOI
10.4070/kcj.2012.42.8.521
Appears in Collections:
의과대학 > 의학과 > Journal papers
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