View : 514 Download: 0
Contributors of the severity of airflow limitation in COPD patients
- Title
- Contributors of the severity of airflow limitation in COPD patients
- Authors
- Hong Y.; Chae E.J.; Seo J.B.; Lee J.-H.; Kim E.-K.; Lee Y.K.; Kim T.-H.; Kim W.J.; Lee J.H.; Lee S.-M.; Lee S.; Lim S.Y.; Shin T.R.; Yoon H.I.; Sheen S.S.; Ra S.W.; Lee J.S.; Huh J.W.; Lee S.-D.; Oh Y.-M.
- Ewha Authors
- 이진화
- SCOPUS Author ID
- 이진화
- Issue Date
- 2012
- Journal Title
- Tuberculosis and Respiratory Diseases
- ISSN
- 1738-3536
- Citation
- Tuberculosis and Respiratory Diseases vol. 72, no. 1, pp. 8 - 14
- Indexed
- SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background: Although airway obstruction in chronic obstructive pulmonary disease (COPD) is due to pathologic processes in both the airways and the lung parenchyma, the contribution of these processes, as well as other factors, have not yet been evaluated quantitatively. We therefore quantitatively evaluated the factors contributing to airflow limitation in patients with COPD. Methods: The 213 COPD patients were aged >45 years, had smoked >10 pack-years of cigarettes, and had a post-bronchodilator forced expiratory volume in one second (FEV 1)/forced vital capacity (FVC) <0.7. All patients were evaluated by medical interviews, physical examination, spirometry, bronchodilator reversibility tests, lung volume, and 6-minute walk tests. In addition, volumetric computed tomography (CT) was performed to evaluate airway wall thickness, emphysema severity, and mean lung density ratio at full expiration and inspiration. Multiple linear regression analysis was performed to identify the variables independently associated with FEV 1 - the index of the severity of airflow limitation. Results: Multiple linear regression analysis showed that CT measurements of mean lung density ratio (standardized coefficient β= -0.46; p<0.001), emphysema severity (volume fraction of the lung less than -950 HU at full inspiration; β= -0.24; p<0.001), and airway wall thickness (mean wall area %; β= -0.19, p=0.001), as well as current smoking status (β = -0.14; p=0.009) were independent contributors to FEV 1. Conclusion: Mean lung density ratio, emphysema severity, and airway wall thickness evaluated by volumetric CT and smoking status could independently contribute to the severity of airflow limitation in patients with COPD. Copyright©2012. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
- DOI
- 10.4046/trd.2012.72.1.8
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML