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Lack of association between the Klotho gene and COPD

Title
Lack of association between the Klotho gene and COPD
Authors
Kim W.J.Oh Y.-M.Kim T.-H.Lee J.-H.Kim E.-K.Lee J.H.Lee S.-M.Shin T.R.Yoon H.I.Lim S.-Y.Lee S.D.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2011
Journal Title
Tuberculosis and Respiratory Diseases
ISSN
1738-3536JCR Link
Citation
vol. 71, no. 4, pp. 254 - 258
Indexed
SCOPUS; KCI scopus
Abstract
Background: Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity. Methods: A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear, regression was performed to investigate their association with emphysema severity in COPD subjects. Results: The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity. Conclusion: Genetic polymorphisms of the klotlto gene were not associated with COPD in a Korean population. Copyright©2011. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
DOI
10.4046/trd.2011.71.4.254
Appears in Collections:
의과대학 > 의학과 > Journal papers
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