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Clinical applications of radio-frequency ablation in liver metastasis of colorectal cancer

Title
Clinical applications of radio-frequency ablation in liver metastasis of colorectal cancer
Authors
Gwak J.H.Oh B.-Y.Lee R.A.Chung S.S.Kim K.H.
Ewha Authors
김광호이령아정순섭
SCOPUS Author ID
김광호scopus; 이령아scopus; 정순섭scopus
Issue Date
2011
Journal Title
Journal of the Korean Society of Coloproctology
ISSN
2093-7822JCR Link
Citation
vol. 27, no. 4, pp. 202 - 210
Indexed
SCOPUS scopus
Abstract
Purpose: The aim of this study is to evaluate long-term survival and prognostic factors for radio-frequency ablation (RFA) in colorectal liver metastases. Methods: We retrospectively reviewed 35 colorectal liver metastases patients who underwent RFA between 2004 and 2008. We analyzed survival after RFA and prognostic factors for survival. Results: Of the 35 patients, 23 patients were male and 12 were female. Their mean age was 62.40 ± 12.52 years. Mean overall survival was 38.8 ± 4.6 months, and mean progression free survival was 19.9 ± 3.4 months. Three- and 5-year overall survival rates were 42.7 ± 0.1% and 26.0 ± 0.1%, respectively. Three- and 5-year progression-free survival rates were 19.6 ± 0.1% and 4.9 ± 0.04%, respectively. Overall survival and progression-free survival were significantly improved in male and in patients with carcinoembryonic antigen (CEA) ≤ 100 ng/mL, carbohydrate antigen (CA) 19-9 ≤ 100 ng/mL, absence of extrahepatic disease, and a unilobar hepatic lesion. In addition, progression-free survival was improved in patients with a solitary hepatic lesion. On the multivariate analysis, significant survival factors were the absence of extrahepatic disease and the presence of a unilobar hepatic lesion. Conclusion: RFA for colorectal liver metastases is an effective treatment option in male patients and in patients with CEA or CA19-9 ≤ 100, absence of extrahepatic disease, a solitary hepatic lesion, and a unilobar hepatic lesion. © 2011 The Korean Society of Coloproctology.
DOI
10.3393/jksc.2011.27.4.202
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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