Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지은 | * |
dc.contributor.author | 류인균 | * |
dc.date.accessioned | 2016-08-28T11:08:29Z | - |
dc.date.available | 2016-08-28T11:08:29Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0003-990X | * |
dc.identifier.other | OAK-13609 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229578 | - |
dc.description.abstract | Context: A multiwave longitudinal neuroimaging study in a cohort of direct survivors of a South Korean subway disaster, most of whom recovered from posttraumatic stress disorder 5 years after trauma, provided a unique opportunity to investigate the brain correlates of recovery from a severe psychological trauma. Objectives: To investigate region-specific brain mobilization during successful recovery from posttraumatic stress disorder by assessing cortical thickness multiple times from early after trauma to recovery, and to examine whether a brain-derived neurotrophic factor gene polymorphism was associated with this brain mobilization. Design: Five-year follow-up case-control study conducted from 2003-2007. Setting: Seoul National University and Hospital. Participants: Thirty psychologically traumatized disaster survivors and 36 age- and sex-matched control group members recruited from the disaster registry and local community, respectively, who contributed 156 highresolution brain magnetic resonance images during 3 waves of assessments. Main Outcome Measures: Cerebral cortical thickness measured in high-resolution anatomic magnetic resonance images using a validated cortical thickness analysis tool and its prospective changes from early after trauma to recovery in trauma-exposed individuals and controls. Results: Trauma-exposed individuals had greater dorsolateral prefrontal cortical (DLPFC) thickness 1.42 years after trauma (right DLPFC, 5.4%; left superior frontal cortex, 5.8%; and left inferior frontal cortex, 5.3% [all clusters, P≤.01]) relative to controls. Thicknesses gradually normalized over time during recovery. We found a positive linear trend, with trauma-exposed individuals with a valine/valine genotype having the greatest DLPFC cortical thickness, followed by those with a methionine genotype and controls (P<.001 for trend). Greater DLPFC thickness was associated with greater posttraumatic stress disorder symptom reductions and better recovery. Conclusion: The DLPFC region might play an important role in psychological recovery from a severely traumatic event in humans. ©2011 American Medical Association. All rights reserved. | * |
dc.language | English | * |
dc.title | The neurobiological role of the dorsolateral prefrontal cortex in recovery from trauma: Longitudinal brain imaging study among survivors of the South Korean subway disaster | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 68 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 701 | * |
dc.relation.lastpage | 713 | * |
dc.relation.journaltitle | Archives of General Psychiatry | * |
dc.identifier.doi | 10.1001/archgenpsychiatry.2011.70 | * |
dc.identifier.wosid | WOS:000292356600006 | * |
dc.identifier.scopusid | 2-s2.0-79960314263 | * |
dc.author.google | Lyoo I.K. | * |
dc.author.google | Kim J.E. | * |
dc.author.google | Yoon S.J. | * |
dc.author.google | Hwang J. | * |
dc.author.google | Bae S. | * |
dc.author.google | Kim D.J. | * |
dc.contributor.scopusid | 김지은(55353332200) | * |
dc.contributor.scopusid | 류인균(55664289900) | * |
dc.date.modifydate | 20240220114752 | * |