Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김경효 | * |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1783-1061 | * |
dc.identifier.other | OAK-13602 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229571 | - |
dc.description.abstract | Purpose: The purpose of this study was to evaluate the immune response to serotype 19A in children aged 12-23 months after immunization of the 19F containing 7-valent pneumococcal conjugate vaccine (PCV7). Methods: Blood samples from a total of 45 subjects (age 12-23 months) were included in the study. Subjects were categorized according to immunization status into three groups as follows: 18 subjects with 3 primary doses and 1 booster dose of PCV7 (booster group), 21 subjects with 3 primary doses before 12 months of age (primary group), and 6 subjects with no vaccination history of PCV7 (control group). An ELISA and opsonophagocytic killing assay (OPKA) was done to evaluate the immune responses against serotypes 19F and 19A. Results: According to the ELISA, all subjects had antibody titers ≥0.35 μg/mL for serotypes 19F and 19A in the booster and primary group and 83.0% and 66.7% in the control group, respectively. According to the OPKA, subjects with opsonic activity (≥20) against serotypes 19F and 19A were 100% and 61.1% of the subjects in the booster group and 66.7% and 19.0% in the primary group, respectively. No subjects in the control group had opsonic antibodies against both serotypes. Conclusion: In conclusion, in children 12-23 months age who were previously vaccinated with PCV7, a cross-reactive immune response is elicited against serotype 19A after a primary series of 3 doses in a small proportion of subjects, and this response is amplified after booster vaccination. © 2011 by The Korean Pediatric Society. | * |
dc.language | English | * |
dc.title | Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 54 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 163 | * |
dc.relation.lastpage | 168 | * |
dc.relation.journaltitle | Korean Journal of Pediatrics | * |
dc.identifier.doi | 10.3345/kjp.2011.54.4.163 | * |
dc.identifier.scopusid | 2-s2.0-79959840070 | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Park S.E. | * |
dc.author.google | Kim K.H. | * |
dc.contributor.scopusid | 김경효(35448653000) | * |
dc.date.modifydate | 20240301081003 | * |