Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤의중 | - |
dc.date.accessioned | 2016-08-28T11:08:27Z | - |
dc.date.available | 2016-08-28T11:08:27Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.other | OAK-13587 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229558 | - |
dc.description.abstract | Tumor necrosis factor α (TNF-α), which is a primary cytokine responsible for inflammatory responses in skin, induces the synthesis of matrix metalloproteinase-9 (MMP-9), which causes skin aging. The protective effects of 3-deoxysappanchalcone against TNF-α-induced damage was investigated using human skin keratinocytes. The results showed that 3-deoxysappanchalcone inhibited MMP-9 expression at the protein and mRNA level, by blocking the activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). Taken together, the inhibitory activity of 3-deoxysappanchalcone on MMP-9 expression and production in TNF-α-treated cells was found to be mediated by the suppression of AP-1 and NF-κB activation. © 2011 Pharmaceutical Society of Japan. | - |
dc.language | English | - |
dc.title | 3-Deoxysappanchalcone inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in human keratinocytes through activated protein-1 inhibition and nuclear factor-kappa B DNA binding activity | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 34 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 890 | - |
dc.relation.lastpage | 893 | - |
dc.relation.journaltitle | Biological and Pharmaceutical Bulletin | - |
dc.identifier.doi | 10.1248/bpb.34.890 | - |
dc.identifier.wosid | WOS:000291117400019 | - |
dc.identifier.scopusid | 2-s2.0-79958018646 | - |
dc.author.google | Youn U.J. | - |
dc.author.google | Nam K.-W. | - |
dc.author.google | Kim H.-S. | - |
dc.author.google | Choi G. | - |
dc.author.google | Jeong W.S. | - |
dc.author.google | Lee M.Y. | - |
dc.author.google | Chae S. | - |
dc.contributor.scopusid | 윤의중(55012159500) | - |
dc.date.modifydate | 20230616155155 | - |