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Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009

Title
Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009
Authors
Cho H.K.Lee N.Y.Lee H.Kim H.S.Seo J.W.Hong Y.M.Lee S.J.Lee S.W.Cheon D.S.Hong J.Y.Kang B.H.Kim J.-H.Kim K.-H.
Ewha Authors
이승주홍영미김경효서정완이선화김혜순
SCOPUS Author ID
이승주scopusscopus; 홍영미scopus; 김경효scopus; 서정완scopus; 이선화scopus; 김혜순scopus
Issue Date
2010
Journal Title
Korean Journal of Pediatrics
ISSN
1783-1061JCR Link
Citation
vol. 53, no. 5, pp. 639 - 643
Indexed
SCOPUS scopus
Abstract
Purpose: Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have been reported. The clinical characteristics in children with neurologic manifestations of EV71 were studied in Ewha Womans University Mokdong Hospital. Methods: Examinations for EV71 were performed from the stools, respiratory secretion or CSF of children who presented neurologic symptoms associated with HFMD by realtime PCR. Clinical and radiologic data of the patients were collected and analyzed. Results: EV71 was isolated from the stool of 16 patients but not from respiratory secretion or CSF. Among the 16 patients, meningitis (n=10) was the most common manifestation, followed by Guillain-Barré syndrome (n=3), meningoencephalitis (n=2), poliomyelitis-like paralytic disease (n=1), and myoclonus (n=1). Gene analysis showed that most of them were caused by EV71 subgenotype C4a, which was prevalent in China in 2008. Conclusion: Because EV71 causes severe complications and death in children, a surveillance system to predict upcoming outbreaks should be established and maintained and adequate public health measures are needed to control disease. © 2010 by The Korean Pediatric Society.
DOI
10.3345/kjp.2010.53.5.639
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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