Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박시훈 | - |
dc.date.accessioned | 2016-08-28T11:08:23Z | - |
dc.date.available | 2016-08-28T11:08:23Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.other | OAK-13533 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229512 | - |
dc.description.abstract | Background and Objectives: The aim of this study was to evaluate the efficacy of lacidipine in reducing blood pressure (BP) and to determine its effect on endothelial function in mild-to-moderate hypertensive patients with type 2 diabetes mellitus (DM). Subjects and Methods: This was a prospective, multicenter, open-label, single-arm study, enrolling 290 patients with mild-to-moderate hypertension and type 2 DM. Patients were initially treated with 2 mg lacidipine orally once daily for 4 weeks, which was then increased as necessary every 4 weeks to a maximal dose of 6 mg daily. The primary endpoint was the mean change in systolic blood pressure (SBP) from baseline after 12 weeks of treatment. Secondary endpoints included mean changes in diastolic blood pressure (DBP), flow-mediated vasodilatation (FMD), and serum concentrations of biochemical markers such as high-sensitivity C-reactive protein (hs-CRP), monocyte chemo-attractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor-1 (PAI-1). Results: Lacidipine treatment significantly reduced SBP by -13.4±13.0 mmHg (p<0.001) and DBP by -6.2±9.3 mmHg (p<0.001). Lacidipine treatment did not improve endothelial-dependent vasodilatation, despite significantly improved nitroglycerin-induced, endothelial-independent vasodilatation. MCP-1 levels significantly decreased from 283.66±110.08 pg/mL to 257.83±100.23 pg/mL (p<0.001); whereas there were no significant changes in the levels of hs-CRP, MMP-9, or PAI-1. Conclusion: Twelve weeks of treatment with lacidipine was effective and well tolerated in mild-to-moderate hypertensive patients with type 2 DM. In spite of inducing a significant reduction in MCP-1 levels, lacidipine did not improve endothelial function. Copyright © 2010 The Korean Society of Cardiology. | - |
dc.language | English | - |
dc.title | Effect of lacidipine on blood pressure and endothelial function in mild-to-moderate essential hypertension patients with diabetes in Korea | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 40 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 632 | - |
dc.relation.lastpage | 638 | - |
dc.relation.journaltitle | Korean Circulation Journal | - |
dc.identifier.doi | 10.4070/kcj.2010.40.12.632 | - |
dc.identifier.scopusid | 2-s2.0-79551696061 | - |
dc.author.google | Kim D.-H. | - |
dc.author.google | Oh I.-Y. | - |
dc.author.google | Lee H.-Y. | - |
dc.author.google | Kim Y.-J. | - |
dc.author.google | Kim H.-S. | - |
dc.author.google | Kim C.-H. | - |
dc.author.google | Oh B.-H. | - |
dc.author.google | Kim K.-S. | - |
dc.author.google | Kim D.-I. | - |
dc.author.google | Kim Y.-D. | - |
dc.author.google | Ryu K.-H. | - |
dc.author.google | Park S.-H. | - |
dc.author.google | Baek S.-H. | - |
dc.author.google | Shin D.-G. | - |
dc.author.google | Shim W.J. | - |
dc.author.google | Ahn T.-H. | - |
dc.author.google | Oh S.-K. | - |
dc.author.google | Lee S.-H. | - |
dc.author.google | Lee S.-Y. | - |
dc.author.google | Jeong M.-H. | - |
dc.author.google | Chung W.-S. | - |
dc.author.google | Jeong J.-Y. | - |
dc.author.google | Choi S.-Y. | - |
dc.author.google | Choi S.-W. | - |
dc.author.google | Hyon M.-S. | - |
dc.contributor.scopusid | 박시훈(9737584900;57191750840) | - |
dc.date.modifydate | 20221123115020 | - |