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Effect of lacidipine on blood pressure and endothelial function in mild-to-moderate essential hypertension patients with diabetes in Korea

Title
Effect of lacidipine on blood pressure and endothelial function in mild-to-moderate essential hypertension patients with diabetes in Korea
Authors
Kim D.-H.Oh I.-Y.Lee H.-Y.Kim Y.-J.Kim H.-S.Kim C.-H.Oh B.-H.Kim K.-S.Kim D.-I.Kim Y.-D.Ryu K.-H.Park S.-H.Baek S.-H.Shin D.-G.Shim W.J.Ahn T.-H.Oh S.-K.Lee S.-H.Lee S.-Y.Jeong M.-H.Chung W.-S.Jeong J.-Y.Choi S.-Y.Choi S.-W.Hyon M.-S.
Ewha Authors
박시훈
SCOPUS Author ID
박시훈scopus
Issue Date
2010
Journal Title
Korean Circulation Journal
ISSN
1738-5520JCR Link
Citation
vol. 40, no. 12, pp. 632 - 638
Indexed
SCIE; SCOPUS; KCI scopus
Abstract
Background and Objectives: The aim of this study was to evaluate the efficacy of lacidipine in reducing blood pressure (BP) and to determine its effect on endothelial function in mild-to-moderate hypertensive patients with type 2 diabetes mellitus (DM). Subjects and Methods: This was a prospective, multicenter, open-label, single-arm study, enrolling 290 patients with mild-to-moderate hypertension and type 2 DM. Patients were initially treated with 2 mg lacidipine orally once daily for 4 weeks, which was then increased as necessary every 4 weeks to a maximal dose of 6 mg daily. The primary endpoint was the mean change in systolic blood pressure (SBP) from baseline after 12 weeks of treatment. Secondary endpoints included mean changes in diastolic blood pressure (DBP), flow-mediated vasodilatation (FMD), and serum concentrations of biochemical markers such as high-sensitivity C-reactive protein (hs-CRP), monocyte chemo-attractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor-1 (PAI-1). Results: Lacidipine treatment significantly reduced SBP by -13.4±13.0 mmHg (p<0.001) and DBP by -6.2±9.3 mmHg (p<0.001). Lacidipine treatment did not improve endothelial-dependent vasodilatation, despite significantly improved nitroglycerin-induced, endothelial-independent vasodilatation. MCP-1 levels significantly decreased from 283.66±110.08 pg/mL to 257.83±100.23 pg/mL (p<0.001); whereas there were no significant changes in the levels of hs-CRP, MMP-9, or PAI-1. Conclusion: Twelve weeks of treatment with lacidipine was effective and well tolerated in mild-to-moderate hypertensive patients with type 2 DM. In spite of inducing a significant reduction in MCP-1 levels, lacidipine did not improve endothelial function. Copyright © 2010 The Korean Society of Cardiology.
DOI
10.4070/kcj.2010.40.12.632
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의학전문대학원 > 의학과 > Journal papers
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