Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.contributor.author | 김혜순 | * |
dc.contributor.author | 손세정 | * |
dc.date.accessioned | 2016-08-28T11:08:21Z | - |
dc.date.available | 2016-08-28T11:08:21Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1738-5520 | * |
dc.identifier.other | OAK-13499 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229484 | - |
dc.description.abstract | Background and Objectives: The pathogenesis of hyponatremia (serum sodium <135 mEq/L) in Kawasaki disease (KD) remains unclear. We investigated the clinical significance of hyponatremia, and the role of interleukin (IL)-6 and IL-Iβ in the development of hyponatremia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) in KD. Subjects and Methods: Fifty KD patients were prospectively enrolled and analyzed for clinical and laboratory variables according to the presence of hyponatremia or SIADH. Results: Thirteen KD patients (26%) had hyponatremia and 6 of these had SIADH. In patients with hyponatremia, the percentage of neutrophils (% neutrophils), C-reactive protein (CRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were higher than in those without hyponatremia, while serum triiodothyronine (T3) and albumin were lower. Patients with hyponatremia had a higher incidence of intravenous immunoglobulin-resistance but this was not statistically significant. No differences existed between patients with and without SIADH with regard to clinical or laboratory variables and the incidence of IVIG-resistance. Serum sodium inversely correlated with % neutrophils, CRP, and NT-proBNP, and positively correlated with T3 and albumin. Serum IL-6 and IL-1β levels increased in KD patients and were higher in patients with hyponatremia. Plasma antidiuretic hormone increased in patients with SIADH, which tended to positively correlate with IL-6 and IL-1β levels. Conclusion: Hyponatremia occurs in KD patients with severe inflammation, while increased IL-6 and IL-1β may activate ADH secretion, leading to SIADH and hyponatremia in KD. Copyright © 2010 The Korean Society of Cardiology. | * |
dc.language | English | * |
dc.title | Hyponatremia and syndrome of inappropriate antidiuretic hormone secretion in Kawasaki disease | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 40 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 507 | * |
dc.relation.lastpage | 513 | * |
dc.relation.journaltitle | Korean Circulation Journal | * |
dc.identifier.doi | 10.4070/kcj.2010.40.10.507 | * |
dc.identifier.scopusid | 2-s2.0-78649434211 | * |
dc.author.google | Lim G.-W. | * |
dc.author.google | Lee M. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Hong Y.M. | * |
dc.author.google | Sohn S. | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.contributor.scopusid | 김혜순(55663596500) | * |
dc.contributor.scopusid | 손세정(56577409300) | * |
dc.date.modifydate | 20240415130647 | * |