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Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera

Title
Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera
Authors
Youn U.J.Lee J.-H.Lee Y.J.Nam J.W.Bae H.Seo E.-K.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2010
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
vol. 7, no. 9, pp. 2296 - 2302
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Four known alkyl 4-hydroxybenzoates, i.e., methyl 4-hydroxybenzoate (1), ethyl 4-hydroxybenzoate (2), propyl 4-hydroxybenzoate (3), and butyl 4-hydroxybenzoate (4), were isolated from the seeds of Nelumbo nucifera GAERTNER (Nymphaeaceae) for the first time. The structures of the isolates were identified by 1D- and 2D-NMR spectroscopy and comparison with published values. The compounds were evaluated for their effects on the 5-HT-stimulated inward current (I5-HT) mediated by the human 5-HT3A receptors expressed in Xenopus oocytes. Compounds 1 and 2 enhanced the I5-HT, but 4 reduced it. These results indicate that 4 is an inhibitor of the 5-HT 3A receptors expressed in Xenopus oocytes. © 2010 Verlag Helvetica Chimica Acta AG.
DOI
10.1002/cbdv.200900393
Appears in Collections:
약학대학 > 약학과 > Journal papers
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