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Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals
- Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals
- Park J.K.; Koh W.-J.; Kim D.K.; Kim E.K.; Kim Y.I.; Kim H.J.; Kim T.-H.; Kim J.Y.; Park M.S.; Park I.-N.; Park J.S.; Lee K.M.; Song S.H.; Lee J.H.; Lee S.H.; Lee H.P.; Yim J.-J.; Lim J.; Jegal Y.J.; Jung K.H.; Huh J.W.; Choi J.C.; Shim T.S.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Tuberculosis and Respiratory Diseases
- Tuberculosis and Respiratory Diseases vol. 69, no. 2, pp. 95 - 102
- SCOPUS; KCI
- Document Type
- Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75-80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea. Copyright©2010. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
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