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Analysis of risk factors for low bone mineral density in patients with inflammatory bowel disease

Title
Analysis of risk factors for low bone mineral density in patients with inflammatory bowel disease
Authors
Park J.J.Jung S.A.Noh Y.W.Kang M.J.Jung J.M.Kim S.E.Jung H.K.Shim K.N.Kim T.H.Yoo K.Moon I.H.Hong Y.S.
Ewha Authors
문일환유권정성애홍영선정혜경심기남김태헌김성은
SCOPUS Author ID
문일환scopus; 유권scopus; 정성애scopus; 홍영선scopus; 정혜경scopus; 심기남scopus; 김태헌scopus; 김성은scopus
Issue Date
2010
Journal Title
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
ISSN
1598-9992JCR Link
Citation
vol. 55, no. 4, pp. 237 - 244
Indexed
SCOPUS; KCI scopus
Abstract
BACKGROUND/AIMS: Several clinical risk factors for low bone mineral density (BMD) in the patients with inflammatory bowel disease (IBD) have been suggested. However, its prevalence and pathophysiology in Korean population have not been fully studied. The aim of this study was to investigate the prevalence and risk factors for low BMD in Korean IBD patient. METHODS: BMD of the lumbar spine and femur was evaluated using dual-energy X-ray absorptiometry in 30 patients with IBD. Biochemical parameters of bone metabolism, such as serum calcium, phosphorus, osteocalcin, and deoxypyridinoline were measured. The associations between low BMD and clinical parameters such as disease duration, disease activity, drug history, body mass index (BMI), and others were evaluated retrospectively using medical records. RESULTS: Low BMD at the lumbar spine or femur was observed in 63.3% of the patients, and there was no significant difference between the patients with Crohns disease and ulcerative colitis. Clinical and biochemical parameters were irrelevant to BMD. In the patients without glucocorticoid treatment prior to BMD measurement, already 50.0% of patients had low BMD. CONCLUSIONS: Low BMD is a common feature in Korean IBD patients, even those who do not use glucocorticoid. The multiple factors may be involved in the pathogenesis of low BMD. Therefore, BMD should be examined in all IBD patients, irrespective of glucocorticoid treatment.
DOI
10.4166/kjg.2010.55.4.237
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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