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Detection of virulence genes of Staphyloccus aureus and Staphylococcus epidermidis isolated from suprapubic urine from infants with fever

Title
Detection of virulence genes of Staphyloccus aureus and Staphylococcus epidermidis isolated from suprapubic urine from infants with fever
Authors
Park H.-K.Woo S.-Y.Jung Y.-J.Lee E.O.Cha J.-E.Park H.-S.Lee S.-J.
Ewha Authors
박혜경이승주박혜숙우소연
SCOPUS Author ID
박혜경scopus; 이승주scopusscopus; 박혜숙scopus; 우소연scopus
Issue Date
2008
Journal Title
Journal of Bacteriology and Virology
ISSN
1598-2467JCR Link
Citation
Journal of Bacteriology and Virology vol. 38, no. 4, pp. 189 - 196
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
While methicillin-resistant Staphylococcus aureus (MRSA) isolated from urinary tract infection (UTI) has recently increased in elderly adult urology patients, it has been only rarely reported in infants. Therefore, in this study to understand whether MRSA may be involved in UTI of infants who run fever without other apparent causes, we identified and counted S. aureus and S. epidermidis in suprapubic urine from 750 febrile infants via microbiological methods, and confirmed the counts via multiplex PCR. And we also detected four virulence genes, mecA, PVL, bbp and icaA genes for S. aureus and S. epidermidis via multiplex PCR in the same specimens. S. aureus (28 cases) counts were as follows: >104 CFU/ml (3/28), 1021O3 CFU/ml (1/28) and <102-103CFU/ml (24/28). S. epidermidis (26 cases) counts were as follows: >104 CFU/ml (2/26), 102~ 103 CFU/ml (4/26) and 102~ 103 CFU/ml (20/26). S. aureus virulence genes were detected in 26 cases as mecA (16/26, 59.3%), PVL (17/26, 63.0%), bbp (7/26, 26.9%) and icaA (20/26, 76.9%). S. epidermidis virulence genes were detected in 22 cases as mecA (17/22, 81.0%), PVL (15/22, 71.4%), bbp (3/22,13.6%) and icaA (13/22, 50.1%). Therefore, mecA, PVL and icaA genes of MRSA and MRSE were detected with high positivity in urines from infants with fever. The results demonstrate that community-acquired MRSA or MRSE may be responsible for UTI incidence in febrile infants.
DOI
10.4167/jbv.2008.38.4.189
Appears in Collections:
의과대학 > 의학과 > Journal papers
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