Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김윤진 | * |
dc.date.accessioned | 2016-08-28T11:08:15Z | - |
dc.date.available | 2016-08-28T11:08:15Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 2005-6419 | * |
dc.identifier.other | OAK-13421 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229420 | - |
dc.description.abstract | Background: The aim of this study was to examine the cardiac function and transcriptional response of the heart to propofol after ischemia-reperfusion. Methods: Rat hearts were Langendorff-perfused using the modified Krebs-Henseleit buffer, and took 20 min stabilizing periods, 40 min ischemia periods, and then 120 min reperfusion period. The hearts were divided into 5 groups; Control: 180 min perfusion after stabilization, Ischemic: 40 min global ischemia after stabilization, followed by 120 min reperfusion, Pre: 2 μM propofol treatment was preformed only before ischemia, Post: 2 μM propofol treatment was performed only during reperfusion after ischemia, Pre/Post: 2 μM propofol treatment was performed both before and after ischemia. The measurement for cardiac performances, such as left ventricular developed pressure (LVDP), rate of left ventricular pressure generation (dP/dt), heart rate, and coronary flow were obtained. The expression profiles of isolated mRNA were determined by using Agilent microarray and real time-polymerase chain reaction (RT-PCR) was used to confirm the microarray results for a subset of genes. Results: The Post group showed better LVDP and dP/dt than the Ischemic group. But there were no significant differences in heart rate and coronary flow among the groups. On the results of RT-PCR, the expressions of Abcc9, Bard1, and Casp4 were increased, but the expressions of Lyz, Casp8, and Timp1 were decreased in the Post group compared with the Ischemic group. Conclusions: This study suggests that 2 μM propofol may provide cardioprotective effect, and modulate gene expression such as apoptosis, and KATP ion channel related-genes during reperfusion in the isolated rat hearts. Copyright © Korean Society of Anesthesiologists, 2010. | * |
dc.language | English | * |
dc.title | Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heart | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 58 | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 153 | * |
dc.relation.lastpage | 161 | * |
dc.relation.journaltitle | Korean Journal of Anesthesiology | * |
dc.identifier.doi | 10.4097/kjae.2010.58.2.153 | * |
dc.identifier.scopusid | 2-s2.0-77953460044 | * |
dc.author.google | Youn J.K. | * |
dc.author.google | Hae J.L. | * |
dc.author.google | Sung U.C. | * |
dc.contributor.scopusid | 김윤진(35069757100) | * |
dc.date.modifydate | 20240123093251 | * |