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dc.contributor.author김광호*
dc.contributor.author이령아*
dc.date.accessioned2016-08-28T11:08:14Z-
dc.date.available2016-08-28T11:08:14Z-
dc.date.issued2010*
dc.identifier.issn2093-7822*
dc.identifier.otherOAK-13414*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/229413-
dc.description.abstractPurpose: Inositol hexaphosphate (IP6) is a naturally occurring poryphosphorylated carbohydrate that has been shown to suppress the growth of epithelial cancer. Because IP6 is a dietary phytochemical present in cereals, soy, legumens, and fiber-rich foods, we evaluated the efficacy of IP6 against colon cancer formation. Methods: HT-29 cells were injected into nude mice. The animals were fed a normal diet (group 1), a low IP6 diet (group 2), and a high IP6 diet (group 3) for 4 wk. Body weight, tumor volume, tumor growth rate, growth inhibition rate, and therapeutic ratio were monitored after injection of HT-29 cells. Results: HT-29-cell human-colon-carcinoma xenograft mice treated with IP6 showed a significant reduction in tumor growth rate, irrespective of the IP6 dose compared to normal diet group. Compared with the control group, group 3 showed a significant reduction (45%) in tumor volume. In the therapeutic ratio gain profiles, IP6 diet groups showed a significant alteration of therapeutic ratio when compared with the normal diet group (0% vs. 11%, P=0.014). In the body weight gain profiles, group 3 showed a significant reduction of body weight compared with the other two groups (20.25 g vs. 21.6 g, 21.7 g, P=0.009). Groups 1 and 2 showed similar changes in body weight. Tumor xenografts from IP6-fed mice showed significantly decreased cancer formation and growth, but increased toxicity was noted for high doses of IP6. Conclusion: These results indicate that in the future, IP6 could be an effective chemopreventive or chemotherapeutic agent for use in the treatment of colon cancer. ©2010 The Korean Society of Coloproctology.*
dc.languageKorean*
dc.titleAnticancer effects of IP6 in a human colon carcinoma cell line in nude mice xenografts*
dc.typeArticle*
dc.relation.issue2*
dc.relation.volume26*
dc.relation.indexSCOPUS*
dc.relation.startpage93*
dc.relation.lastpage97*
dc.relation.journaltitleJournal of the Korean Society of Coloproctology*
dc.identifier.doi10.3393/jksc.2010.26.2.93*
dc.identifier.scopusid2-s2.0-77953381211*
dc.author.googleKim C.D.*
dc.author.googleLee J.E.*
dc.author.googleLee R.A.*
dc.author.googleKim K.H.*
dc.contributor.scopusid김광호(57192983544)*
dc.contributor.scopusid이령아(12753883700)*
dc.date.modifydate20240118124654*
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의과대학 > 의학과 > Journal papers
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