Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김광호 | * |
dc.contributor.author | 이령아 | * |
dc.date.accessioned | 2016-08-28T11:08:14Z | - |
dc.date.available | 2016-08-28T11:08:14Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 2093-7822 | * |
dc.identifier.other | OAK-13414 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229413 | - |
dc.description.abstract | Purpose: Inositol hexaphosphate (IP6) is a naturally occurring poryphosphorylated carbohydrate that has been shown to suppress the growth of epithelial cancer. Because IP6 is a dietary phytochemical present in cereals, soy, legumens, and fiber-rich foods, we evaluated the efficacy of IP6 against colon cancer formation. Methods: HT-29 cells were injected into nude mice. The animals were fed a normal diet (group 1), a low IP6 diet (group 2), and a high IP6 diet (group 3) for 4 wk. Body weight, tumor volume, tumor growth rate, growth inhibition rate, and therapeutic ratio were monitored after injection of HT-29 cells. Results: HT-29-cell human-colon-carcinoma xenograft mice treated with IP6 showed a significant reduction in tumor growth rate, irrespective of the IP6 dose compared to normal diet group. Compared with the control group, group 3 showed a significant reduction (45%) in tumor volume. In the therapeutic ratio gain profiles, IP6 diet groups showed a significant alteration of therapeutic ratio when compared with the normal diet group (0% vs. 11%, P=0.014). In the body weight gain profiles, group 3 showed a significant reduction of body weight compared with the other two groups (20.25 g vs. 21.6 g, 21.7 g, P=0.009). Groups 1 and 2 showed similar changes in body weight. Tumor xenografts from IP6-fed mice showed significantly decreased cancer formation and growth, but increased toxicity was noted for high doses of IP6. Conclusion: These results indicate that in the future, IP6 could be an effective chemopreventive or chemotherapeutic agent for use in the treatment of colon cancer. ©2010 The Korean Society of Coloproctology. | * |
dc.language | Korean | * |
dc.title | Anticancer effects of IP6 in a human colon carcinoma cell line in nude mice xenografts | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 26 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 93 | * |
dc.relation.lastpage | 97 | * |
dc.relation.journaltitle | Journal of the Korean Society of Coloproctology | * |
dc.identifier.doi | 10.3393/jksc.2010.26.2.93 | * |
dc.identifier.scopusid | 2-s2.0-77953381211 | * |
dc.author.google | Kim C.D. | * |
dc.author.google | Lee J.E. | * |
dc.author.google | Lee R.A. | * |
dc.author.google | Kim K.H. | * |
dc.contributor.scopusid | 김광호(57192983544) | * |
dc.contributor.scopusid | 이령아(12753883700) | * |
dc.date.modifydate | 20240118124654 | * |