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Fumonisin B1 induces apoptosis in sphingosine 1-phosphate lyase-null F9 cells through increase of sphingolipids levels

Title
Fumonisin B1 induces apoptosis in sphingosine 1-phosphate lyase-null F9 cells through increase of sphingolipids levels
Authors
Pak S.-M.Park N.-Y.Park M.-Y.Kim W.-J.Lee J.-H.Oh S.Yoo H.-S.Lee Y.-M.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2008
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 16, no. 2, pp. 95 - 99
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Apoptosis is essential for a variety of pathophysiological progress. Apoptosis induction by various agents changes cellular morphology, DNA content and lipid membrane composition. Recently, sphingosine 1-phosphate (S1P) is avidly released from not only platelets and erythrocytes but vascular endothelium. Here we established S1P releasing cells by deleting S1P lyase (F9-12 cells). We observed apoptosis induction by the treatment of fumonisin B1 (FB1) in F9-12 cells but not in F9 wild-type cells. We measured high amounts of accumulated S1P and dihydroS1P (DHS1P) in FB1-induced apoptotic F9-12 cells. We also showed DHS1P release in an early stage of the apoptosis induction by FB1 but not by phorbol 12-myristate 13-acetate (PMA)-induced apoptosis, suggesting differential apoptotic processes.
DOI
10.4062/biomolther.2008.16.2.095
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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