Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유권 | * |
dc.contributor.author | 정성애 | * |
dc.contributor.author | 이주호 | * |
dc.contributor.author | 심기남 | * |
dc.contributor.author | 김성은 | * |
dc.date.accessioned | 2016-08-28T11:08:59Z | - |
dc.date.available | 2016-08-28T11:08:59Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1976-2283 | * |
dc.identifier.other | OAK-13236 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229259 | - |
dc.description.abstract | Background/Aims: Hypoxia-inducible factor-1α (HIF-1α) is a mediator of tumor progression. Vascular endothelial growth factor (VEGF) is the most potent angiogenic factor known to be induced by HIF-1α. We investigated the clinicopathological significance of HIF-1α and VEGF levels in biopsied gastric cancer tissue. Methods: Endoscopic biopsy specimens from 67 patients with gastric carcinoma who underwent surgery were available for this study. Semiquantitative RT-PCR was applied to biopsied tumors and normal tissues to determine the expressions of HIF-1α and VEGF. The expression levels of HIF-1α and VEGF were evaluated using the tumor:normal (T/N) ratios of HIF-1α and VEGF mRNA. The clinicopathological variables were reviewed retrospectively. Results: The T/N ratios of HIF-1α mRNA showed significant correlation with lymph-node metastases, distant metastases, stage, and recurrence within 3 years (p<0.05). The T/N ratios of VEGF mRNA showed significant correlation with lymph-node metastases and distant metastases (p<0.05). There was a significant correlation between the T/N ratios of HIF-1α and VEGF mRNA (r=0.72, p<0.01). Conclusions: The increased expression of HIF-1α and VEGF mRNA could reflect aggressive tumor behavior, including the recurrence of gastric cancer. Examination of HIF-1α mRNA in biopsy specimens by RT-PCR assay might provide useful preoperative information on tumor aggressiveness. | * |
dc.language | English | * |
dc.title | The clinicopathological significance of tissue levels of hypoxia-inducible factor-1α and vascular endothelial growth factor in gastric cancer | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 3 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 88 | * |
dc.relation.lastpage | 94 | * |
dc.relation.journaltitle | Gut and Liver | * |
dc.identifier.doi | 10.5009/gnl.2009.3.2.88 | * |
dc.identifier.wosid | WOS:000266715700003 | * |
dc.identifier.scopusid | 2-s2.0-67649300463 | * |
dc.author.google | Kim S.-E. | * |
dc.author.google | Shim K.-N. | * |
dc.author.google | Jung S.-A. | * |
dc.author.google | Yoo K. | * |
dc.author.google | Joo H.L. | * |
dc.contributor.scopusid | 유권(7202592827) | * |
dc.contributor.scopusid | 정성애(7403676915) | * |
dc.contributor.scopusid | 이주호(55689891300) | * |
dc.contributor.scopusid | 심기남(13604838300) | * |
dc.contributor.scopusid | 김성은(35210756100;57204243828) | * |
dc.date.modifydate | 20240422125929 | * |