View : 16 Download: 0

Prevalence and risk factors of osteoporosis in patients with chronic obstructive pulmonary disease

Title
Prevalence and risk factors of osteoporosis in patients with chronic obstructive pulmonary disease
Authors
Sim Y.S.Lee J.H.Ryu Y.J.Chun E.M.Chang J.H.
Ewha Authors
장중현이진화천은미류연주
SCOPUS Author ID
장중현scopus; 이진화scopus; 천은미scopus; 류연주scopus
Issue Date
2009
Journal Title
Tuberculosis and Respiratory Diseases
ISSN
1738-3536JCR Link
Citation
vol. 66, no. 3, pp. 186 - 191
Indexed
SCOPUS; KCI scopus
Abstract
Background: Osteoporosis is a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD). This study examined the prevalence and risk factors associated with osteoporosis in patients with COPD. Methods: The bone mineral densities (BMDs) of the lumbar spine and femoral bone were measured in 53 patients with clinically stable COPD and 41 age- and gender-matched control subjects showing a normal lung function. Osteoporosis was defined as a T-score ≤-2.5. The subjects' clinical characteristics and laboratory data were reviewed, and multiple logistic regression analysis was used to identify the risk factors associated with osteoporosis in COPD patients. Results: The prevalence of osteoporosis was 47% and 32% in the COPD patients and controls, respectively. In particular, using the femoral neck T-score, the prevalence of osteoporosis in COPD patients was higher than that in the controls (26% vs. 5%; p=0.006). The average T-score of the lumbar spine (p=0.025) and femoral neck of COPD patients were significantly lower than those of the controls (p=0.001). The forced expiratory volume in the 1 second (FEV 1) % predicted (p=0.019; odds ratio [OR], 0.955; 95% confidence interval [CI], 0.919-0.993) and age (p=0.024; OR, 1.144; 95% CI, 1.018-1.287) were independently associated with osteoporosis in patients with COPD. Conclusion: Using the femoral neck T-score, the prevalence of osteoporosis in patients with COPD was higher than the age-and gender-matched controls. A lower FEVi and older age further increase the risk of osteoporosis in patients with COPD. Copyright © 2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
DOI
10.4046/trd.2009.66.3.186
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE