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Synthesis of fluoroneplanocin A

Title
Synthesis of fluoroneplanocin A
Authors
Jeong L.S.Tosh D.K.Choi W.J.Pal S.
Ewha Authors
정낙신최원준
Issue Date
2008
Journal Title
Current Protocols in Nucleic Acid Chemistry
ISSN
1934-9270JCR Link
Citation
no. SUPPL. 34, pp. 14.6.1 - 14.6.18
Indexed
SCOPUS scopus
Abstract
Fluoroneplanocin A, designed as a potent mechanism-based irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH), is synthesized from D-ribose via a key D-cyclopentenone intermediate. This intermediate is synthesized using a stereoselective Grignard reaction, a ring-closing metathesis (RCM) reaction, and oxidative rearrangement as key steps. © 2008 by John Wiley & Sons, Inc.
DOI
10.1002/0471142700.nc1406s34
Appears in Collections:
약학대학 > 약학과 > Journal papers
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