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Can the PDE5 inhibitor replace intracavernosal injection as a method for inducing a penile erection during the evaluation of erectile dysfunction using penile duplex ultrasonography?

Title
Can the PDE5 inhibitor replace intracavernosal injection as a method for inducing a penile erection during the evaluation of erectile dysfunction using penile duplex ultrasonography?
Authors
Ryu I.W.Yoon H.Shim B.S.Park Y.Y.Chung W.S.
Ewha Authors
박영요심봉석정우식윤하나
SCOPUS Author ID
박영요scopus; 심봉석scopus; 정우식scopus; 윤하나scopus
Issue Date
2008
Journal Title
Korean Journal of Urology
ISSN
0494-4747JCR Link
Citation
vol. 49, no. 7, pp. 641 - 646
Indexed
SCOPUS scopus
Abstract
Purpose: To clarify whether vardenafil can be used as a substitute for intracavernosal injection as a method of induction of penile erection, we compared the outcome of penile duplex Doppler ultrasonography using both methods in the same patient with erectile dysfunction. Materials and Methods: A total of 23 patients underwent penile duplex ultrasonography twice with a one week interval between procedures. Twelve were randomly selected for intracavernosal injection first with prostaglandin E1 (PGE1) 20 μg and the remaining 11 were initially treated with oral vardenafil 20mg 1 hour before the Doppler study and in addition had visual sexual stimulation using a head-mounted display during the study. The peak systolic velocity (PSV), end diastolic velocity (EDV) and the degree of maximum erectile response were measured and compared between the two groups. Results: Measurements from the PGE1 treatment were not significantly different from those with the vardenafil treatment. The percentage of compatibility between the two methods with regard to hemodynamic diagnosis and pharmaceutical erectile response was as high as 83% (19 of 23) and 91% (21 of 23), respectively. Both methods were tolerable and safe without severe complications. However, in 4 patients where the diagnosis was uncertain, the injection method provided a more accurate interpretation of the penile vascular status with duplex ultrasonography. Conclusions: These results suggest that oral vardenafil can be used as an initial method for inducing penile erection when assessing erectile dysfunction with penile duplex Doppler ultrasonography in selected patients with erectile dysfunction.
DOI
10.4111/kju.2008.49.7.641
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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