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A multicenter prospective study of the effect of imipramine and desmopressin on arousability in children with nocturnal enuresis

Title
A multicenter prospective study of the effect of imipramine and desmopressin on arousability in children with nocturnal enuresis
Authors
Kim J.M.Kim Y.S.Namgoong M.K.Park K.H.Park Y.H.Lee S.D.Lee S.J.Chung J.Y.
Ewha Authors
이승주
SCOPUS Author ID
이승주scopusscopus
Issue Date
2008
Journal Title
Korean Journal of Urology
ISSN
0494-4747JCR Link
Citation
vol. 49, no. 2, pp. 168 - 173
Indexed
SCOPUS scopus
Abstract
Purpose: We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis (NE). Materials and methods: The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1 (imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2 (desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data. Results: Mean wetting events in group 1 decreased from 8.8 to 5.1 times (2 weeks) and 3.0 times (4 weeks) (p=0.009) versus 10.2 to 5.5 times (2 weeks) and 6.4 times (4 weeks) (p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9 (baseline), 4.4 (2 weeks), and 3.7 (4 weeks), and, for group 2, 5.1 (baseline), 4.8 (2 weeks), and 4.8 (4 weeks). The two groups were not different (p=0.14, p=0.73). Conclusions: Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability.
DOI
10.4111/kju.2008.49.2.168
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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