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Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3

Title
Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3
Authors
Ebert A.D.Hoo J.H.Bohn M.C.
Ewha Authors
한후재
SCOPUS Author ID
한후재scopus
Issue Date
2008
Journal Title
Journal of Neuroscience Research
ISSN
0360-4012JCR Link
Citation
vol. 86, no. 2, pp. 317 - 325
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
6-Hydroxydopamine (6-OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease (PD) in rodents. In the rat model of PD first described by Sauer and Oertel, DA neurons progressively die over several weeks following a striatal injection of 6-OHDA. It is generally assumed that DA neurons die through apoptosis after exposure to 6-OHDA, but data supporting activation of a caspase enzymatic cascade are lacking. In this study, we sought to determine if caspases involved in the intrinsic apoptotic cascade play a role in the initial stages of 6-OHDA-induced death of DA neurons in the progressively lesioned rat model of PD. We found that injection of 6-OHDA into adult rat striatum did not activate caspase-9 or caspase-3 or increase levels of caspase-dependent cleavage products in the substantia nigra at various survival times up to 7 days after the lesion, even though this paradigm produced DA neuronal loss. These data suggest that in the adult rat brain DA neurons whose terminals are challenged with 6-OHDA do not die through a classical caspase-dependent apoptotic mechanism. © 2007 Wiley-Liss, Inc.
DOI
10.1002/jnr.21480
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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