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Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole

Title
Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole
Authors
Jung H.Kim H.-M.Choy Y.B.Hwang S.-J.Choy J.-H.
Ewha Authors
최진호황성주
SCOPUS Author ID
최진호scopus; 황성주scopus
Issue Date
2008
Journal Title
International Journal of Pharmaceutics
ISSN
0378-5173JCR Link
Citation
vol. 349, no. 41276, pp. 283 - 290
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Laponite, a form of layered aluminosilicates, and itraconazole, a water insoluble drug, were hybridized through an interfacial reaction at the boundary between water and a water-immiscible liquid. The reaction was carried out under a controlled pH to maintain both physical and chemical stability of the drug. The X-ray diffraction patterns and spectroscopic analyses indicated that itraconazole was intercalated into the interlayer space of clay with a lateral monolayer structure. No significant chemical structural change of itraconazole was seen through the formation of the hybrid. The hybrid system exhibited enhanced solubility and controlled release of itraconazole. The released amount of itraconazole could be controlled in the range from 18 to 75%, depending on the kinds of cations in the release media. © 2007 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ijpharm.2007.08.008
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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