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Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head, and neck squamous cell carcinoma cell lines

Title
Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head, and neck squamous cell carcinoma cell lines
Authors
Lee D.W.Park S.-W.Park S.-Y.Heo D.-S.Kim K.H.Sung M.-W.
Ewha Authors
박수연
Issue Date
2004
Journal Title
Head and Neck
ISSN
1043-3074JCR Link
Citation
vol. 26, no. 8, pp. 706 - 715
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Background. Although cyclooxygenase-2 (COX-2) has been suggested to play an important role in carcinogenesis, the effects of tumor suppressors on COX-2 gene expression and the combined antitumor effects of tumor suppressors and COX-2 inhibitors have rarely been investigated. Methods. The effects of p53 or p27 gene transfer on COX-2 expression by adenoviral vector and the combined effects of p53 or p27 gene transfer and COX-2 inhibitor exposure on the proliferation of cancer cells were investigated in head and neck squamous cell carcinoma (HNSCC) cell lines. Results. Overexpression of p53 markedly downregulated the transcription of COX-2, but the overexpression of p27 did not affect COX-2 levels in HNSCC cell lines. The combined antitumor effects of p53 or p27 gene transfer and of a COX-2 inhibitor (NS 398) were mainly at least additive in terms of the inhibition of cell proliferation and cell cycle arrest and additive in terms of apoptotic induction. Conclusions. These results suggest that the overexpression of p53 could exert antitumor effects, at least in part, through the suppression of COX-2 gene expression, whereas growth suppression by the overexpression of p27 probably occurs by mechanisms other than the downregulation of COX-2 expression. In addition, the administration of COX-2 inhibitors, as an adjunct to p53 or p27 gene therapy, could offer a new strategy of cancer treatment and prevention. © 2004 Wiley Periodicals, Inc.
DOI
10.1002/hed.20025
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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