Topographical functionalization of ordered mesoporous silica

Abstract

Multi-functionalized MCM-41 has been successfully synthesized by site-selective manipulation of pore surface. The external surface of as-synthesized MCM-41 including surfactant template was deactivated by replacing the hydroxyl group with the highly electronegative fluorine. It allows one to fabricate the nanovessel with desired functionalities for the advanced applications such as targeted drug delivery.