Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하은희 | * |
dc.contributor.author | 김영주 | * |
dc.contributor.author | 박혜숙 | * |
dc.contributor.author | 이화영 | * |
dc.contributor.author | 우소연 | * |
dc.date.accessioned | 2016-08-28T11:08:40Z | - |
dc.date.available | 2016-08-28T11:08:40Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0188-4409 | * |
dc.identifier.other | OAK-12986 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229038 | - |
dc.description.abstract | Background: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction by reversibly blocking NO production from L-arginine. To elucidate the association of prenatal status of ADMA with placental heat-shock protein 70 (HSP70) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in normal full-term pregnancies, we evaluated the expression of placental HSP70 and LOX-1. Methods: Tissue samples of placentas obtained from 60 normal-term pregnancies were categorized into 30 cases with a lower level of prenatal ADMA (0.28 ± 0.07 μM) and 30 cases with a higher level of prenatal ADMA (1.31 ± 0.44 μM). We evaluated the placental expression of HSP70 and LOX-1 with Western blot analysis and immunohistochemistry and determined the correlation between HSP70 and LOX-1. Results: We found that prenatal increased ADMA is associated with increased placental HSP70 and LOX-1 expression. Conclusions: We postulate that higher ADMA levels are associated with excessive levels of oxidative damage and stress markers (HSP, LOX-1) in placental tissues. © 2007 IMSS. | * |
dc.language | English | * |
dc.title | Prenatal Increased Asymmetric Dimethylarginine Is Associated with Placental Heat-Shock Protein 70 and Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Expression | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 38 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 839 | * |
dc.relation.lastpage | 845 | * |
dc.relation.journaltitle | Archives of Medical Research | * |
dc.identifier.doi | 10.1016/j.arcmed.2007.05.005 | * |
dc.identifier.wosid | WOS:000250489400006 | * |
dc.identifier.scopusid | 2-s2.0-34848873808 | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Jeon Y.J. | * |
dc.author.google | Ahn Y.M. | * |
dc.author.google | Lee H.Y. | * |
dc.author.google | Woo S.Y. | * |
dc.author.google | Park H.S. | * |
dc.author.google | Ha E.H. | * |
dc.author.google | Pang M.G. | * |
dc.contributor.scopusid | 하은희(7003615774) | * |
dc.contributor.scopusid | 김영주(55801681000) | * |
dc.contributor.scopusid | 박혜숙(57201862679;56148186100) | * |
dc.contributor.scopusid | 이화영(57207324935) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.date.modifydate | 20240419135248 | * |