View : 26 Download: 0

Botulinum toxin A for the management of vulvodynia

Title
Botulinum toxin A for the management of vulvodynia
Authors
Yoon H.Chung W.S.Shim B.S.
Ewha Authors
심봉석정우식윤하나
SCOPUS Author ID
심봉석scopus; 정우식scopus; 윤하나scopus
Issue Date
2007
Journal Title
International Journal of Impotence Research
ISSN
0955-9930JCR Link
Citation
vol. 19, no. 1, pp. 84 - 87
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Clinically, botulinum toxin A blocks the cholinergic innervation of the target tissue. Recently, it has been proved effective not only at a neuromuscular junction but also within parasympathetic or sympathetic neural synapses. Seven women with pain on genitalia that could not be controlled with conventional pain managements were enrolled in this study. Twenty to 40 U of botulinum toxin A were used in each injection. Injection sites were the vestibule, levator ani muscle or the perineal body. Repeat injections were administered every 2 weeks if the patient's symptoms had not fully subsided. In all patients, pain had disappeared with botulinum toxin A injections. Five patients needed to be injected twice; the other two patients needed only one injection. We did not observe complications related to botulinum toxin A injections, such as pain, hemorrhage, infection, muscle paralysis or other complications. The subjective pain score improved from 8.3 to 1.4, and no one has experienced a recurrence (the follow-up period was four to 24 months, with a mean follow-up of 11.6 months). Botulinum toxin A is effective in blocking nociception. Even though further investigation and well-controlled study will be necessary, we suggest that the botulinum toxin therapy would be useful and safe in managing vulvodynia of muscular or neuroinflammatory origins. © 2007 Nature Publishing Group All rights reserved.
DOI
10.1038/sj.ijir.3901487
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE